How does the plant regulate receptor signaling to balance immune response and growth? (MENKE_S16WDTP)

植物通过检测病原体相关分子模式（PAMP）来感知微生物病原体，这是由细胞表面局部模式识别受体（PRR）介导的。PAMPs的感知触发了一个信号网络，包括有丝分裂原活化蛋白激酶（MAPK）的激活，防御基因表达的激活，最终导致PAMP触发免疫（PTI）。对PAMPs的感知也通过大多数未知的信号事件导致生长抑制。由于生长调控也涉及受体介导的植物多肽感知，因此存在交叉调控的可能性。一些联系已经被确定，表明PRR信号和植物肽信号之间的一些信号成分是共享的，例如共受体BAK1(1)。此外，植物多肽的感知最近也与防御反应的负调控和抑制对微生物病原体的抗性有关（2,3）。目前的项目研究PRR信号和植物肽信号控制生长之间的联系。在当前的项目中，基于受体的信号事件将通过先进的蛋白质组学方法和细胞生物学（使用共聚焦显微镜）进行研究。

Plants sense microbial pathogens through the detection of pathogen associated molecular patterns (PAMP) and this is mediated by cell surface localised pattern recognition receptors (PRR). Perception of PAMPs triggers a signaling network that includes activation of mitogen activated protein kinases (MAPK), activation of defence gene expression and ultimately leads to PAMP triggered immunity (PTI). Perception of PAMPs also leads to growth inhibition, by mostly unknown signaling events. Since the regulation of growth also involves receptor-mediated perception of plant peptides there is potential for cross regulation. Some connections have already been identified that suggest some of the signaling components are shared between PRR signaling and plant peptide signaling, such at co-receptor BAK1 (1). Furthermore, perception of plant peptides has recently also been linked to negative regulation of defense response and suppresses resistance to microbial pathogens (2,3). The current project investigates the links between PRR signaling and plant peptide signaling controlling growth. In the current project the receptor based signaling event will be studied with advanced proteomics approaches and cell biology (using confocal microscopy).