Effects of Increased Endolymph Volume on Cochlear and Vestibular Function and Morphology of Inner Ear Tissues

我们最近的研究表明，在梅尼埃病等疾病中，与内耳液体体积增大相关的眩晕发作可能是在液体压力迫使位于连接听力和平衡器官的液体管道中的组织瓣膜打开时引发的。该项目旨在确定这些瓣膜的功能作用，并开发一种由于水肿而导致前庭活动突然变化的动物模型，以便开发未来的治疗方法。

Our recent research suggests that the vertigo attacks associated with enlarged fluid volumes in the inner ear, in diseases such as Ménière's Disease, maybe triggered when the fluid pressure forces open tissue valves located in the fluid-ducts connecting the hearing and balance organs. This project aims to identify the functional role of these valves, and to develop an animal model of abrupt changes in vestibular activity due to hydrops, to allow future treatments to be developed.