Mechanisms of Cardiovascular Disease and Gene Therapy

描述（申请人的摘要）我们的多学科培训补助金的更新申请提供博士和博士后水平的培训。 自最初的申请以来，我们为大学和培训补助金增加了新的相关教师。 培训教师作为一个群体，代表了所有级别的资历，他们的研究涵盖了心血管研究培训的许多重要方面，从基础细胞生物学，到整个动物和人类生理学，再到基因治疗。 我们的培训计划包括4个领域：1）基因治疗，2）基因操作/基因图谱，3）肌节和细胞骨架，4）心血管发育和功能。 博士前学员将获得两个部门之一的博士学位：分子，细胞和发育生物学（MCDB）或运动学。正式的课程和资格考试是必需的。博士后学员（PhD，MD或MD-PhD）将在实验室工作2-3年，根据他们的背景，他们可能会参加分子遗传学的研究生课程。心脏病学研究员的MD申请人将在研究任期之前或之后获得临床心脏病学培训。 自上次申请以来，博尔德和丹佛健康科学公司成立了一家心血管研究所，该研究所的培训师都是会员。 此外，我们还与丹佛的MD-PhD项目建立了正式联系，允许这些学生在博尔德完成论文工作。 这项培训补助金可以促进这些企业。

DESCRIPTION (Applicant's Abstract) This application for renewal of our multidisciplinary training grant provides training at the doctoral and postdoctoral levels. Since the original application, we have added new relevant faculty to the University and to the training grant. The training faculty, as a group, represents all levels of seniority and their research covers many important aspects of cardiovascular research training ranging from basic cell biology, to whole animal and human physiology to gene therapy. Our training program consists of 4 areas: 1) Gene Therapy, 2) Genetic Manipulation/Gene Mapping, 3) The Sarcomere and the Cytoskeleton, 4) Cardiovascular Development and Function. Predoctoral trainees will receive the PhD degree from one of two departments: Molecular, Cellular and Developmental Biology (MCDB), or Kinesiology. Formal course work and a Qualifying Exam are required. Postdoctoral trainees (either PhD), MD, or MD-PhD) will spend 2-3 years in the laboratory, and depending on their background, they may participate in a graduate course in Molecular Genetics. MD applicants who are Cardiology Fellows will obtain their clinical cardiology training either before or after their research tenure. Since the last application, a Cardiovascular Research Institute has been established as a joint venture between Boulder and Health Sciences in Denver and the trainers on this application are all members. In addition, we have established a formal link with the MD-PhD) program in Denver that allows those students to do their thesis work in Boulder. This training grant can facilitate those ventures.