Conference on Molecular Biology of the Heart

描述(申请人提供)：本次研讨会的重点将放在 使用分子和遗传工具了解心血管发育， 功能和疾病。这是这个领域非常激动人心的时刻，我们将 信息爆炸式增长的优势 多个生物体的基因组计划。到那时为止的基因发现 会议无疑将是相当先进的，我们应该有关于 小鼠心血管疾病相关基因表达的变化 还有男人。另一个令人兴奋的“热门”研究领域是茎的可能性 心脏中的细胞。我们将专门举行一次会议，讨论 心脏干细胞。模式生物体的使用使开发 早期心脏形成的范例，我们将使用这些研究的例子 探索脊椎动物和无脊椎动物心脏发育。单基因疾病 贡献了大量关于先天性和成人心脏的信息 从瓣膜和间隔障碍到年轻人猝死的疾病 运动员。我们将探索单基因疾病，但也会导致 对高血压和高血压等复杂遗传性疾病的理解 易患心脏病。另一个新兴的研究领域是我们的 理解导致心力衰竭的分子机制的能力， 北美最流行的疾病和死因。会议将是 开发的是“床到床”处理心脏疾病的精髓 失败与如何在基础研究的基础上发展治疗范式 调查结果。这次研讨会将汇聚来自产业界、临床医生 和基础研究，以服务于Keystone研讨会的使命。 这将是一次多学科的会议，应该把以下人员聚集在一起 开始定期对话，但他们的传统在某种程度上 分开。

DESCRIPTION (provided by applicant): The focus of this symposium will be on the use of molecular and genetic tools to understand cardiovascular development, function and disease. It is a very exciting time in this field and we will take advantage of the veritable explosion in information that has resulted from the genome projects of multiple organisms. Gene discovery by the time of this meeting will undoubtedly be quite advanced and we should have information about the changes in gene expression that accompany cardiovascular disease in mice and men. Another exciting "hot" area of investigation is the potential for stem cells in the heart. We will devote a session to the promise and practice of cardiac stem cells. The use of model organisms has made it possible to develop paradigms for early heart formation and we will use examples of these studies to explore vertebrate and invertebrate heart development. Single gene disorders have contributed a great deal of information about congenital and adult cardiac disease ranging from valve and septal disorders to sudden death in young athletes. We will explore single gene disorders, but also approaches leading to the understanding of complex genetic disorders such as hypertension and predisposition for heart disease. Another emerging area of research is our ability to understand the molecular mechanisms leading to cardiac failure, the most prevalent disease and cause of death in North America. Sessions will be developed that are the essence of "bench-to-bedside" dealing with cardiac failure and how to develop treatment paradigms based on basic research findings. This symposium will bring together people from industry, clinicians and basic research in a way that serves the mission of the Keystone symposium. It will be a multidisciplinary meeting that should bring together people who are beginning to have regular dialogues but whose traditions have been somewhat separate.