POTENTIAL PATHOGEN WITH TROPHISM FOR GASTRIC MUCIN

描述（根据应用改编）：一个品种的大比例 发生在工业化国家的胃病， 幽门螺杆菌感染。但部分患者 患有这些症状是培养阴性和抗体阴性， H.幽门螺杆菌，这些疾病往往归因于其他原因， 例如习惯性使用某些药物。有报道称 提出作为病原体的未表征的球状生物体 有些病人有胃炎，球形体已经被 在胃活检样本中检测到。实验证明， 球形体在传播感染上已不可能 因为球状体不能在实验室中培养。一 最近从获得的活检材料中培养出球形生物体 来自患有革兰氏胃炎的患者。分离菌株的原型， 命名为SL-100的菌株感染猪胃窦并结合 猪胃粘蛋白的体外表达。这些观察表明， 从这些胃病患者中分离出的球形生物可能是人类 病原体本研究的主要目的是：（1）进一步 表征菌株SL-100和相关分离物，和（2）确定 在这个国家和国外，感染或疾病的发生率，由于 这个物种。PI将检测正常和感染的血清样本 测试针对这种生物体的抗体。他 目前在纽约地区有临床合作者， 最初的目标将是尝试从活检中培养生物体 材料，并确定是否针对特定的抗体 微生物蛋白与感染或疾病有关。

Description (Adapted from Application): A large proportion of a variety of gastric disorders occurring in the industrialized countries have been attributed to infections by Helicobacter pylori. However, some patients suffering these symptoms are culture negative and antibody negative for H. pylori, and these disorders are often attributed to other causes, such as the habitual use of certain drugs. There have been reports of uncharacterized coccoid organisms proposed as the causative agent for gastric inflammation in some patients, and coccoid forms have been detected in gastric biopsy samples. Experimental proof of a role of the coccoid forms in the transmission of infection has not been possible because the coccoid forms could not be cultivated in the laboratory. A coccoid organism was recently cultivated from biopsy material obtained from patients suffering gram gastritis. The prototype isolate, designated strain SL-100, infects the porcine gastric antrum and binds to porcine gastric mucin in vitro. These observations suggest that the coccoid organisms isolated from these gastric patients may be human pathogens. Major goals of the proposed research are to (1) further characterize strain SL-100 and related isolated, and (2) determine the incidence, in this country and abroad, of infection or disease due to this species. The PI will test serum samples from normal and infected individuals to test for antibodies specific for this organism. He currently has clinical collaborators in the New York area, and the initial goal will be to attempt to cultivate the organism from biopsy material and to determine if antibodies directed against specific microbial proteins are correlated with infection or disease.