STANFORD ALZHEIMER'S DISEASE CORE CENTER

这一申请反映了斯坦福大学对阿尔茨海默病(AD)研究的持续承诺。自从13年前国家精神卫生研究所(NIMH)开始研究老年人的精神病理学以来，我们有一个NIMH中心，专注于AD的研究。类似于AIA的“阿尔茨海默病核心中心(ADCC)”，我们的NIMH中心的结构专注于AD的研究。与NIA“阿尔茨海默病核心中心”(ADCC)类似，NIMH中心的结构一直是一个“使能或核心中心”，旨在利用“核心资源”促进独立资助的AD研究的发展。我们认为，我们在这方面的努力是成功的，利用该中心的核心在斯坦福大学产生了资助的广告项目。我们未来的计划是作为ADCC继续沿着这条轨道前进，因为我们中心的目标和结构与NIA计划的任务更一致，而不是与新的NIMH计划更一致，鉴于我们作为已建立核心的使能中心的历史，我们认为我们非常适合完成这一过渡。我们中心的主要焦点一直是AD异质性方面的研究。在目前的应用中，我们扩大了我们建议的ADCC的重点，以促进三个主要领域的研究：病因、疾病进展和AD相关行为症状的病理生理学。这项工作将与大学在基础神经科学和遗传学、神经成像和睡眠/时间生物学方面的主要研究计划紧密结合。我们的期望是，我们不仅将促进这三个单独领域的研究，而且由于我们的跨学科经验，我们将促进跨越学科和增加思想交流的研究努力。我们认为，这种多因素和跨学科的方法可能最好地解决当前AD研究的复杂问题。

This application reflects the continuing commitment of Stanford University to the study of Alzheimer's Disease (AD). Since the inception of the National Institute of Mental Health (NIMH) program for the Study of Psychopathology in the Elderly over 13 years ago, we have had an NIMH Center focusing on the study of AD. Similar to the AIA "Alzheimer's Disease Core Center (ADCC)," the structure of our NIMH Center focusing on the study of AD. Similar to the NIA "Alzheimer's Disease Core Centers (ADCC), the structure of NIMH Center has been that of an "enabling or core center" designed to use "core resources" to facilitate the development of independently funded research on AD. We feel that we been successful in this endeavor, producing funded AD projects at Stanford using the Center's core. Our plan for the future is to continue along this track as an ADCC because the objectives and structure of our Center our Center are more consistent with the mandate of the NIA program than with new NIMH programs that will no long support "core centers" Given our log history as an enabling center with established cores, we feel that we are ideally suited to accomplish this transition. The primary focus of our Center has been the study of aspects for the heterogeneity of AD. In the current application we have expanded the focus of our proposed ADCC to facilitate research in three major areas: etiology; progression of disease; and pathophysiology of associated behavioral symptoms in AD. This work will be closely integrated with major research programs at the University in basic neurosciences and genetics, neuroimaging, and sleep/chronobiology. Our expectation is that we will not only facilitate research in these three individual areas but also, because of our interdisciplinary experience, we will foster research efforts that bridge disciplines and increase cross-fertilization of ideas. We feel that this multi-factorial and interdisciplinary approach may best address complex questions current to AD research.