Nanoprobes for Molecule-Specific Contrast Enhancement

描述（由申请人提供）：提出了纳米拉曼探针的开发，其将促进单个分子的拉曼散射的检测。拟议的第一阶段研究将集中在纳米粒子系统和分析物纳米粒子复合物的合理设计。纳米颗粒-固态支撑平台也将在拟议的研究中进行优化。在第一阶段的研究中，将建立一种分析复杂细胞系统中单分子振动光谱的策略的可行性。这项研究将导致一个可销售的分析系统的发展，分析单个分子的结构的能力。我们相信，一个强大的敏感拉曼系统的可用性将有广泛的兴趣，从化学和生物医学研究人员。它可能对DNA测序、早期疾病检测和环境监测产生影响。

DESCRIPTION (provided by applicant): Development of nano-Raman probes that will facilitate the detection of Raman scattering of individual molecule is proposed. The proposed phase I research will focus on the rational design of a nanoparticle system and analyte-nanoparticle complex. The nanoparticle-solid state support platform will also be optimized in the proposed research. During the phase I research the feasibility of a strategy for analyzing single molecule vibrational spectrum in complex cellular system will be established. This research will lead to the development of a marketable analytical system with the capability of analyzing the structure of an individual molecule. We believe that the availability of a robust sensitive Raman system will have broad interest from chemical and biomedical researchers. And it might have impact on DNA sequencing, early stage disease detection, and environmental monitoring.