Sonothrombolysis of Vascular Clots with Targeted Bubbles

描述（由申请人提供）：心脏病发作和中风在美国每年造成340万人死亡。此外，血管疾病的发病率也占数十亿美元的医疗保健费用。这些血管疾病的基础通常涉及血管系统中闭塞性凝块的形成，导致血液供应丧失、缺氧和组织死亡。目前的治疗涉及使用以下程序：1）促进纤维蛋白溶解（组织纤溶酶原激活剂），2）防止血液凝固（肝素），3）延迟血小板诱导的凝血（阿司匹林、噻氯匹定）或4）需要外科手术干预（血管成形术、旁路术、经动脉内膜切除术）。这些疗法要么是侵入性的，要么涉及显著的不良反应。我们最近开发了一种靶向微泡，它以高亲和力结合血管内凝块。初步工作表明，这些微泡结合超声可以帮助溶解血管凝块，这是该建议的目的，以确定使用靶向微泡沿着超声作为一种潜在的治疗方式在治疗血管闭塞的可行性和实用性。

DESCRIPTION (provided by applicant): Heart attacks and strokes account for 3.4 million deaths annually in the United States. Moreover, the morbidity from vascular disease accounts for billions of healthcare dollars as well. The basis for these vascular diseases generally involves the formation of occlusive clots in the vasculature, leading to loss of blood supply, anoxia and tissue death. Current treatments involve the use of procedures that 1) promote fibrinolysis (tissue plasminogen activator), 2) prevent blood coagulation (heparin), 3) retard platelet-induced clotting (aspirin, ticlopidine) or 4) require surgical intervention (angioplasty, bypass, transendarterectomy). These therapies are either invasive or involve significant adverse effects. We recently have developed a targeted microbubble that binds to intravascular clots with high avidity. Preliminary work suggests that these microbubbles in conjunction with ultrasound can aid in the dissolution of vascular clots, It is the objective of this proposal to determine the feasibility and practicality of using targeted microbubbles along with ultrasound as a potential therapeutic modality in the treatment of vascular occlusion.