Indole Analogs as Novel Treatments for OCD

描述(申请人提供)：强迫症(OCD)是一种 严重的精神疾病，影响着全世界数百万人。 现有的治疗强迫症的方法疗效有限，可能会有令人担忧的副作用 效果差，往往需要长期治疗。发现一种新的治疗方法 对于强迫症来说，将具有相当大的科学价值和商业价值。这个 然而，致幻剂裸盖菇素已经显示出对强迫症的初步疗效。 即使对这种化合物的进一步研究是积极的，FDA批准 裸盖菇素可能会有问题。在第一阶段，我们建议合成 精心挑选的裸盖菇素类似物。这些化合物的药理作用将 在体外和体内都要进行评估。从这个项目中，我们特别瞄准了 发现一种或多种裸盖菇素类似物在动物模型中显示有效性 对强迫症的疗效与现有疗法相当。这样的结果将 强烈支持在第二阶段继续进行。这个项目的长期目标是 是发现新的、改进的强迫症治疗方法。 拟议的商业应用：发现一种新的、改进的强迫症治疗方法可以减轻世界各地许多人的痛苦，并将具有非常巨大的商业潜力。

DESCRIPTION (provided by applicant): Obsessive Compulsive Disorder (OCD) is a serious mental illness that affects millions of people throughout the world. Existing therapies for OCD show limited efficacy, can possess troubling side effects, and often require long-term treatment. Discovery of a new treatment for OCD would have considerable scientific value and commercial value. The hallucinogen psilocybin has shown preliminary efficacy against OCD, however even if further research on this compound is positive, FDA approval for psilocybin could be problematic. In Phase One we propose to synthesize carefully selected psilocybin analogs. The pharmacology of these compounds will be evaluated both in vitro and in vivo. From this project we specifically aim to discover one or more psilocybin analogs showing efficacy in an animal model for OCD comparable to that of the existing therapies. Such a result will strongly support continuation in Phase Two. The long-term goal of this project is to discover new, improved treatments for OCD. PROPOSED COMMERCIAL APPLICATION: Discovery of a novel, improved therapy for obsessive compulsive disorder could alleviate suffering for many people worldwide and would have very substantial commercial potential.