Electrochemical Enzyme Immunoassay to Test Blood HBV

描述（由申请人提供）：数百万美国人感染了 B型肝炎病毒（HBV）-其中许多人没有理由相信他们是 感染了有必要追踪美国数百万的乙肝病毒受害者， 以及相应地需要创新技术来检测血液中的HBV。 HBV显然是国家医疗优先事项。 该项目的总体目标是进一步开发，然后整合核心 传感器和酶免疫分析技术， 并准确测量血液中的乙型肝炎病毒水平。我们的目标是诊断 （检测）应用以及定量测量需求（监测） 病毒水平和治疗功效）。我们的方法的可行性是 在第一阶段中得到了明确的证明。第二阶段的目标是 演示/验证/优化独特的电化学 专有电化学酶免疫测定法 体系结构，以产生“真实的时间”的新诊断/监测能力， 在门诊环境中进行具有成本效益的HBV评估。 我们设想的产品是一种一次性的HBV测试条，可以由一个 便宜的小型（手持）仪器。这将是一个关键的发展， 在医疗诊断方面， 市场需要低成本的HBV筛查和监测。 拟议商业应用：不可用

DESCRIPTION (provided by applicant):Millions of Americans are infected by the hepatitis B virus (HBV)-many of whom have no reason to believe they are infected. There is a need to track down America's millions of HBV victims-as well as a corresponding need for innovative technology to test blood for HBV. HBV is clearly a national medical priority. The overall goal of this project is to further develop and then integrate core sensor and enzyme immunoassay technologies into a novel technique for the rapid and accurate measurement of HBV levels in blood. We are targeting diagnostic (detection) applications as well as quantitative measurement needs (to monitor viral levels and treatment efficacy). The feasibility of our approach was clearly demonstrated during Phase I. The Phase II goal is to demonstrate/validate/optimize the integration of a unique electrochemical measurement method with proprietary electrochemical enzyme immunoassay architecture to produce a new diagnostic/monitoring capability for "real time," cost-effective HBV assessment in an outpatient setting. The product we envision is a disposable HBV test strip that can be read by an inexpensive, small (hand-held) instrument. It would represent a key development in medical diagnostics that would address major domestic and international market needs for low-cost HBV screening and monitoring. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE