VIBRO-ACOUSTOGRAPHY SYSTEM WITH CONTACT ARRAY PROBE

描述（由申请人提供）：组织的粘弹性是 与组织状态和病理密切相关。振动声成像（VA） 是我们实验室开发的一种新的成像方法， 组织对选定的低振动力的动态响应 频率（kHz范围）。这样的图像可以用于评估组织 病理 振动声成像系统使用超声波的辐射力来产生 一种高度集中的振荡力， 点对象响应由水听器记录并用于产生 形象结果是一个无斑点的横向视图，代表了 物体对振动力的动态响应。初步在 体外实验，我们已经表明，振动声成像可以用来成像 硬物质，如人体动脉内的钙化，非常小， 颗粒，如人体乳腺组织中的微米级微钙化，以及 肝脏病变。VA还可用于成像和评估 人工心脏瓣膜 本建议的目的是开发一种振动声成像系统， 一种用于体内应用的接触探针。这项研究的目标将是 分两个阶段实现。第一阶段包括计算机模拟 the system.第二阶段是系统实施。的目的 第一阶段包括：系统设计、建模和评估系统 性能第二阶段的目标包括设计和建造 超声探头、系统电子学的设计和构造 （发射机、接收机和监视器），以及评估和优化系统 性能这项研究的成功完成将导致一个新的 一类非侵入性成像和组织评估设备，将提供 关于组织的机械特性的信息是不可用的 与其他成像方式不同。

DESCRIPTION (provided by applicant): Viscoelastic properties of tissues are closely related to the tissue state and pathology. Vibro-acoustography (VA) is new imaging method developed in our laboratory that produces a display of the dynamic response of tissue to a vibrating force at a selected low frequency (kHz range). Such images may be used for evaluation of tissue pathology. A vibro-acoustography system uses the radiation force of ultrasound to produce a highly concentrated oscillating force that vibrates the object at each point. Object response is recorded by a hydrophone and used to produce the image. The result is a speckle-free, transverse view, representing the dynamic response of the object to the vibrating force. In preliminary in vitro experiments, we have shown that vibro-acoustography can be used to image hard materials such as calcifications inside human arteries, very small particles such as micron-size microcalcifications in human breast tissue, and lesions in liver. VA can also be used to image and evaluate the integrity of prosthetic heart valves. The purpose of this proposal is to develop a vibro-acoustogrraphy system with a contact probe for in vivo applications. The goal of this research will be achieved in two phases. The first phase consists of computer simulation of the system. The second phase focuses on system implementation. The aims of the first phase include: system design, modeling, and evaluating system performance. The aims of the second phase include design and construction of the ultrasound probe, design and construction of system electronics (transmitter, receiver, and monitor), and evaluating and optimizing system performance. Successful completion of this research will result in a new class of noninvasive imaging and tissue evaluation device, which will provide information about the mechanical properties of tissue that are not available from other imaging modalities.