PHOTODYNAMIC THERAPY--BASIC SCIENCE STUDIES

本计划将继续研究光动力疗法 （PDT）。 五个项目的研究课题包括 细胞对PDT治疗脑肿瘤的临床试验的抵抗 肿瘤的 这些项目得到两项核心活动的支持， 这是其成功开展工作不可或缺的一部分。 该计划的协同作用将 继续依赖于双方之间的有效互动， 科学项目和调查人员。 项目1建议 研究，在体内，可能的方法，以提高有效性， PDT通过增加肿瘤中氧气的可用性， 治疗 项目2提出了PDT治疗的临床试验 恶性脑肿瘤 两项试验涉及Photofrin，一项涉及de 一个用于复发性病变。 项目3将 继续研究细胞对PDT的抗性。 相关知识 这种抗性发展的机制对于 在细胞水平上理解PDT。 项目4将继续 研究PDT剂量学。 本项目建议的研究将 直接影响PDT的临床应用。 项目5将 继续进行体内研究，检查PDT在脑肿瘤中的作用， 正常的大脑 一个重点领域将是调查替代方案， 药物递送方法。 核心将提供全面的技术支持 为了这个项目 设备校准和项目间质量 这一核心将提供保证。

This Program Project will continue to investigate Photodynamic Therapy (PDT). The five projects will cover research topics ranging from cellular resistance to PDT to clinical trials for the treatment of brain tumors. The projects are supported by two core activities which are integral to their successful conduct. The synergy of the Program will continue to depend upon the effective interactions between both the scientific projects and the investigators. Project 1 proposes to investigate, in vivo, possible methods to improve the effectiveness of PDT by increasing availability of oxygen in the tumor at the time of treatment. Project 2 proposes clinical trials of PDT for the treatment of malignant brain tumors. Two trials involving Photofrin, one for de novo and one for recurrent lesions, are planned. Project 3 will continue to investigate cellular resistance to PDT. Knowledge regarding the mechanisms by which such resistance develops is critical to the understanding of PDT at the cellular level. Project 4 will continue to investigate PDT dosimetry. The studies proposed in this project will have a direct impact on the clinical application of PDT. Project 5 will continue its in vivo studies examining PDT effects in brain tumor and normal brain. One area of focus will be to investigate alternate methods of drug delivery. Core will provide overall technical support for the program. Calibration of devices and interproject quality assurance will be provided by this core.