Integrated Bioinformatics Center of Cellular Biology

描述（申请人提供）：本申请旨在开发和 计划在细胞生物学方面建立一个生物信息学卓越中心。的 应用程序的规划方面集中在促进 一群计算科学家和一群生物医学科学家 在计算密集型生物医学研究中。三个发展项目 包括虚拟细胞项目、微阵列项目和 质谱/蛋白质组学项目。三个责任项目 小组共同解决了广泛的研究问题， 从生物学到器官生理学然而，这些群体之间的互动非常频繁， 由于其各自之间的自然相关性， 子学科。计算小组计划引入一系列 创新的解决方案，以计算问题，其中每一个 发展中国家越来越多地面临。计算需要， 将解决的是生物医学研究中的基本问题，因此， 其中提出的新方法将不仅解决推进 参与开发项目，而且还有更广泛的生物医学类 其他地方的应用。计算小组的第二个目标是计划和 建立高性能计算基础设施， 生物信息学研究活动。这一基础设施建设将 最初利用高速网络来互连现有计算机硬件 软件资源目前分散在各个实验室。它 随后将发展成为一个中央计算设施， 生物信息计算 拟议中的生物信息中心将采用一项雄心勃勃的计划， 生物信息学教育和培训计划， 课程开发，学生活动，研讨会和讲习班，博士后 培训、访客计划和共享计算资源。的 中心？的职能还包括组织年度务虚会，以促进 研究人员之间的互动，管理访客计划和实习 与当地生物医学和制药行业合作。最终 该中心的目标是满足日益增长的计算密集型需求， 生物医学研究通过追求研究创新，同时 培养下一代研究人员， 多学科领域。

DESCRIPTION (provided by applicant): This application aims at developing and planning a Bioinformatics Center of Excellence in Cellular Biology. The planning aspect of the application centers on promoting interactions between a group of computational scientists and a group of biomedical scientists engaged in computation intensive biomedical research. The three development projects included are the Virtual Cell project, the Microarray project, and the Mass-Spectrometry/Proteomics project. The respective three responsible project groups collectively address a wide spectrum of research issues from cellular biology to organ physiology. Yet these groups share a very high interaction potential due to the natural relevancy amongst their respective sub-disciplines. The computational group plans to bring in a series of innovative solutions to the computational problems that each of these developmental groups has been increasingly facing. The computational needs that will be addressed are fundamental issues in biomedical research and thus the novel approaches proposed therein will address advancing not only the participating development projects but also a wider class of biomedical applications elsewhere. A second goal of the computational group is to plan and establish a high performance computing infrastructure dedicated to the proposed bioinformatics research activities. This infrastructure development will initially utilize a high-speed network to interlink existing computer hardware and software resources currently scattered around individual laboratories. It will subsequently mature into a central computing facility dedicated to bioinformatic computing. The proposed bioinformatics center will employ an ambitious plan to overhaul bioinformatics education and training programs by officering a focal point for curriculum development, student activities, seminars and workshops, postdoc training, visitors program, and sharing of computational resources. The center?s function also includes organizing annual retreats to promote interactions among researchers, managing visitors programs and internship programs with the local biomedical and pharmaceutical industry. The ultimate goal of the center is to fulfill the growing need of computation intensive biomedical research by pursuing innovation in research and at the same time training the next generation of researchers in this important multi-disciplinary field.