ALEXANDER CENTER FOR CAM, MINORITY AGING AND CVD

与年长的白色美国人相比，年长的非洲裔美国人的发病率、死亡率和残疾率不成比例地高。造成这种健康差异的最大因素是该人群的心血管疾病（CVD）。因此，根据国家研究优先任务，亚历山大CAM研究中心的总体目标，少数民族老龄化和心血管疾病是评估疗效，是评估CAM方法的有效性和机制，以预防这种流行病在老年非裔美国人。亚历山大中心是CAM和传统医学领域领先的学术和临床中心的独特跨学科和多机构合作。这些合作机构在NIH支持的关于CAM模式的有效性和机制的随机对照试验中有着良好的合作记录，特别是在CVD高风险的老年非裔美国人中。参与机构包括：玛赫西管理大学-玛赫西吠陀医学学院，爱荷华州大学医学院，查尔斯R。德鲁医学院，莫尔豪斯医学院和雪松西奈医学中心。本团队进行的初步研究发现，传统吠陀医学的方法，特别是冥想干预，与高血压，心理社会压力，动脉粥样硬化CVD和高血压心脏病的替代终点以及长期随访的死亡率显着降低有关。因此，该中心将开展控制良好的基础和临床研究、开发项目、研究培训，并建立核心服务、行政结构和程序，以支持该研究项目。针对老年高风险非裔美国人人群和核心人群的拟议研究计划包括：1）冥想治疗动脉粥样硬化性心血管疾病机制的基础研究（动脉血管运动、心脏自主神经张力和心理社会风险因素），2）冥想对患有CVD的老年黑人妇女的颈动脉粥样硬化、CVD风险因素、生理机制、心理社会风险因素和生活质量的影响的临床试验，3）传统草药抗氧化剂与常规维生素补充剂相比对颈动脉粥样硬化、内皮功能、氧化应激、CVD危险因素和生活质量的机制和临床效果的对照研究，4）提供组织结构和程序的行政核心，总体咨询理事会，毕业生和研究生CAM研究人员的培训和未来的发展研究，5）生物统计和研究方法核心，为研究项目提供统计和方法支持。总之，亚历山大中心将提供一个独特的和完善的平台，评估和翻译CAM模式，以预防高风险老年非裔美国人的心血管疾病。

Older African Americans suffer from disproportionately high rates of morbidity, mortality, and disability compared to older white Americans. The largest contributor to this health disparity is cardiovascular disease (CVD) in this population. Therefore, in accordance with national research priority mandates, the overall goal of the Alexander Center for Research in CAM, Minority Aging and CVD is to evaluate the efficacy is to evaluate the efficacy and mechanisms of CAM approaches for the prevention of this epidemic disease in older African Americans. The Alexander Center is a unique interdisciplinary and multi-institutional collaboration of leading academic and clinical centers in CAM and conventional medicine. These partner institutions have an established record of collaborating together on NIH-supported randomized controlled trials on the effectiveness and mechanisms of CAM modalities, specifically in older African Americans at high risk for CVD. The participating institutions include: Maharishi University of Management- College of Maharishi Vedic Medicine, University of Iowa College of Medicine, Charles R. Drew University of Medicine, Morehouse School of Medicine and Cedars-Sinai Medical Center. Preliminary studies conducted by the present team have found that approaches of traditional Vedic medicine, in particular meditation intervention, is associated with significant reductions in hypertension, psychosocial stress, surrogate endpoints for atherosclerotic CVD and hypertensive-heart disease, and mortality over long-term follow-up in this aging minority population. Therefore, the Center will conduct well-controlled basic and clinical research, developmental programs, research training, and establish core services, administrative structures and procedures to support this research program. Proposed research programs with older high risk African American populations and cores include: 1) a basic study of mechanisms of meditation on atherosclerotic CVD (arterial vasomotion, cardiac autonomic tone and psychosocial risk factors), 2) a clinical trial of effects of meditation on carotid atherosclerosis, CVD risk factors, physiological mechanisms, psychosocial risk factors and quality of life in older Black women with CVD, 3) a controlled study on mechanisms and clinical effects of a traditional herbal antioxidant compared to conventional vitamin supplementation on carotid atherosclerosis, endothelial function, oxidative stress, CVD risk factors, and quality of life, 4) an Administrative Core to provide organizational structure and procedures, an overall Advisory Council, training of graduate and postgraduate CAM researchers and future developmental studies, 5) a Biostatistical and Research Methods Core that will provide statistical and methodological support for research projects. In conclusion, the Alexander Center will provide a unique and well- established platform for evaluation and translation of CAM modalities for the prevention of CVD in high risk older African Americans.