CORE--ECOGENETICS RESEARCH FACILITY

本核心将重点关注遗传易感性在毒性 对环境因素的反应。 其长期目标是，“ 鉴定和表征与以下差异有关的遗传多态性： 对环境因子的反应-反应也包括肿瘤发生 急性和慢性毒性。“有六个具体目标， 本研究核心：1）阐明基因表达的机制， 通过遗传变异进行调控; 2）筛选种群， 世代家庭的毒性反应差异; 3）确定 遗传位点和表型性状之间的关联; 4） 了解多态性的分子基础; 5）研究 胚胎发生过程中基因和试剂的相互作用;以及6）评估 每个多态性对人类健康的影响。

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, "to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity." There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.