CORE--Cellular responses to DNA damage

描述：研究核心2由一组杰出的 突变和DNA修复领域的研究人员。它包括七个 正式会员和两个二级会员和一个附属会员。的主要目标是 这一核心是协调研究，以了解影响因素 致癌物所致DNA损伤的形成、修复 (例如，NER、碱基切除修复、重组修复)，以及特定的 细胞对DNA损伤的反应。这应该会让我们深入了解 肿瘤的发生机制和其他过程，如细胞凋亡 暴露在环境化学物质中。这有五个具体目标 研究核心：1)保持和扩大智力氛围， 促进信息共享，促进科学发展 准会员，并有非中心科学家参与。2)加强和加强 将合作扩展到未来的计划项目拨款。3)推广新技术 合作解决与环境健康有关的问题。4)至 协调对遗传差异在生物多样性中的作用的理解 对DNA损伤的反应，包括毒性效应的机制。5)至 扩展用于蛋白质和DNA分析的分析技术列表 损害赔偿，既包括损害的类型，也包括损害的敏感性 侦测。

Description: Research core 2 is comprised of a group of outstanding investigators in the area of mutagenesis and DNA repair. It includes seven full and two secondary members and one affiliate. The primary objective of this core is to coordinate research toward understanding the factors affecting the formation of carcinogen-induced DNA damages, the repair of such damages (e.g., NER, base excision repair, recombinational repair), and the specific responses of cells to DNA damage. This should provide an insight into the mechanism of carcinogenesis and other processes such as apoptosis from exposure to environmental chemicals. There are five specific aims of this research core: 1) To maintain and expand an intellectual atmosphere that fosters increased sharing of information, nurtures the scientific growth of associate members, and involve non-Center scientists. 2) To strengthen and expand collaborations toward future program project grants. 3) To promote new collaborations to address problems related to environmental health. 4) To coordinate the understanding of the role of genetic differences in the response to DNA damage, including the mechanism of toxic effects. 5) To expand the list of analytical techniques for the analysis of protein and DNA damages, both in terms of the types of damages and in the sensitivity of detection.