Core--Ovarian cancer clinical network

产品说明：在最基本的分子水平上理解卵巢癌的潜力对科学界提出了挑战，以应用新的和发展中的技术来促进我们对这种致命疾病的理解。目前缺乏的是前瞻性地随访足够大的卵巢癌或卵巢癌家族风险的女性队列，以明确解决这些问题。FCCC建议建立卵巢癌临床网络核心，这是一个以研究为基础的基础设施，旨在促进转化研究的开展，并将新的预防、筛查和治疗策略转化为临床实践。 这个核心代表了气候变化框架公约、福克斯蔡斯网络、库珀医疗中心、天普大学、新泽西癌症研究所、好时医疗中心和宾夕法尼亚大学的伙伴关系，并为广泛的种族、社会经济和农村/城市人口提供了机会。 建立在1600多个高风险乳腺癌家庭的基础设施上，并利用核心设施的综合资源，将收集一个或多个卵巢癌病例的组织病理学记录的家庭队列。 将收集关于医疗、生殖、家庭和生活方式因素的广泛信息。 将采集所有受试者的血液样本。 卵巢组织标本将要求从受影响的个人以及那些未受影响的家庭成员接受卵巢切除术预防。 该核心将设计、开发和支持一个综合信息管理系统，以确保准确的数据输入和维护，并满足SPORE调查人员的需求。 咨询和筛查方案将标准化，并分发给保健专业人员。 该设施将建立在福克斯大通正在进行的开创性工作的基础上，以满足高风险家庭的需求，并将扩大这些努力，以促进多学科研究项目。创建一个动态的卵巢癌研究数据库提供了一个独特的机会，以解决多学科的研究问题，并把遗传革命产生的卵巢癌的知识，以社区。

DESCRIPTION: (Applicant's Description) The potential to understand ovarian cancer at the most basic molecular level poses a challenge to the scientific community to apply the new and developing technologies to advance our understanding of this deadly disease. What has been lacking is the opportunity to prospectively follow a sufficiently large cohort of women with ovarian cancer or with a familial risk for ovarian cancer to definitively address these questions. The FCCC proposes the establishment of The Ovarian Cancer Clinical Network Core, a research-based infrastructure to facilitate the conduct of translational research and to transfer novel prevention, screening and treatment strategies into clinical practice. This core represents a partnership of FCCC, the Fox Chase Network, Cooper Medical Center, Temple University, the Cancer Institute of new Jersey, Hershey Medical Center, and the University of Pennsylvania and provides access to a wide spectrum of ethnic, socioeconomic and rural/urban populations. Building upon an established infrastructure of over 1600 high risk breast cancer families and using the combined resources of the core facility, a cohort of families with histopathologic documentation of one or more cases of ovarian cancer will be assembled. Extensive information on medical, reproductive, family and lifestyle factors will be collected. Blood samples will be collected from all participants. Ovarian tissue specimens will be requested from affected individuals as well as those unaffected family members undergoing oophorectomy for prophylaxis. The core will design, develop, and support a comprehensive information management system to ensure accurate data entry and maintenance and to serve the needs of the SPORE investigators. Counseling and screening protocols will be standardized and disseminated to health care professionals. This facility will build upon the seminal work underway at Fox Chase to serve the needs of high-risk families and will expand these efforts to foster multidisciplinary research projects. The creation of a dynamic ovarian cancer research database provides a unique opportunity to address multidisciplinary research questions and to bring the knowledge about ovarian cancer generated by the genetic revolution to the community.