VASCULAR STIFFNESS AND EFFECTS OF DIETARY INTERVENTION

描述：(改编自《调查者摘要》)血管僵硬可以 被视为血管“生物老化”的一种量度，并且可以是 继发性动脉粥样硬化和/或高血压的早期征兆。这个 研究人类人群中的血管僵硬需要准确和 可重复使用的措施。目前还没有测量的黄金标准。 血管僵硬在流行病学研究中的作用。调查人员建议 为了评估三种不同的技术，脉搏波速度，超声波 压力脉动信号的成像和分析 重复性及其与亚临床颈动脉粥样硬化的关系。 血管硬度将在不同的人群和广泛的 将探索一系列潜在的风险因素。共有1250名受试者 将会被研究。首先，他们将在 在其科室接受颈动脉超声检查的人群 大量的风险因素数据已经可用。其中包括300人 围绝经期妇女、300名绝经后妇女和200名中年(40-70岁) 几年)非裔美国人和高加索人。此外，他们还将招聘200名 年轻人(20-40岁)，非裔美国人和高加索人。他们的 初步数据提示同型半胱氨酸可能与血管 僵硬，这将在非洲裔美国人和 高加索人受试者。最后，额外的营养因素将是 通过对250名受试者进行血管僵硬测量来探索 INTERMAP研究的匹兹堡队列。这将使调查人员能够 评估血管僵硬与详细营养之间的关系 以最先进的方式收集的数据。总而言之， 调查人员表示，这项研究将全面概述 血管硬度测量与年龄、性别、种族、绝经的关系 状态，激素使用，颈动脉粥样硬化，超声心动图检查， 危险因素(包括血压、体重、体脂分布、身体 肥胖，血脂，饮食，钠和钾的排泄，血管反应性， 心理社会变量)以及亚临床和临床心血管疾病 疾病。他们进一步表示，在一个实验室进行这项研究 有了仔细的、可重复的措施，就可以对 血管僵硬，这很可能是 动脉粥样硬化和高血压的风险。

DESCRIPTION: (Adapted from Investigator's Abstract) Vascular stiffening can be viewed as a measure of the "biologic aging" of the vessels and may be an early indication of subsequent atherosclerosis and/or hypertension. The study of vascular stiffness in human populations requires accurate and reproducible measures. There is currently no gold standard for measurement of vascular stiffness in epidemiological studies. The investigators propose to evaluate three different techniques, pulse wave velocity, ultrasound imaging and analysis of the pressure pulsation signal, with respect to their reproducibility and relationship to subclinical carotid atherosclerosis. Vascular stiffness will be evaluated in a variety of populations and a wide range of potential risk factors will be explored. A total of 1250 subjects will be studied. First, they will obtain vascular stiffness measures in populations undergoing carotid ultrasound in their department for whom a wealth of risk factor data are already available. These include 300 perimenopausal women, 300 postmenopausal women, and 200 middle-aged (40 - 70 years) African Americans and Caucasians. In addition, they will recruit 200 young adults (20 - 40 years), African American and Caucasian. Their preliminary data suggest that homocysteine may related to vascular stiffness, and this will be carefully evaluated in African American and Caucasian subjects. Finally, additional nutritional factors will be explored by performing vascular stiffness measures on 250 subjects from the Pittsburgh cohort of the INTERMAP study. This will allow the investigators to evaluate associations between vascular stiffness and detailed nutritional data that have been collected in a state-of-the-art manner. In summary, the investigators state that this study will provide a comprehensive overview of vascular stiffness measures in relationship to age, sex, race, menopausal status, hormone use, carotid atherosclerosis, echocardiographic measures, risk factors (including blood pressure, weight, body fat distribution, body fatness, lipids, diet, sodium and potassium excretion, vascular reactivity, psychosocial variables), and subclinical and clinical cardiovascular disease. They further state that conducting the study in one laboratory with careful, reproducible measures will allow a thorough evaluation of vascular stiffness, which is likely to be an important component of atherosclerosis and hypertension risk.