Elucidating metabolic dysregulation in Alzheimer’s disease: Profiling the peripheral immune cell lipidome to unravel pathological mechanisms.

免疫系统和脂质代谢在阿尔茨海默病（AD）中都起着重要的作用。由于所有试图治疗阿尔茨海默病的临床试验都失败了，我们试图确定一种方法，既能更好地诊断阿尔茨海默病患者，又能识别风险增加的人群。该项目使用一种新的分析技术来表征免疫细胞的脂质组成，以诊断、预测风险、监测疾病并确定潜在的疾病修饰治疗靶点。

Both the immune system and lipid metabolism have been identified to be important in Alzheimer’s disease (AD). With the failures of all clinical trials attempting to treat AD, we seek to determine a way to both better diagnose individuals with AD and to identify people at increased risk. This project uses a novel profiling technique to characterise the lipid composition of immune cells to diagnose, predict risk, monitor the disease and to identify potential disease modifying therapeutic targets.