Dynamic Processing of Otolith Signals During Translation

描述(申请人提供)：前庭-眼反射(VORS)表现 作为综合凝视控制系统的重要组成部分，以确保稳定 在运动过程中对环境的感知。而旋转VOR(RVOR) 在行为和神经生理层面上都有很好的特征， 平移VOR(TVOR)的神经回路和计算 还不太为人所知。尽管有相似的功能目标，但不同的时间 感觉和运动水平的反射特性意味着需要 对耳道信号和耳石信号进行不同的动态处理。此外， 翻译过程中适当的反射行为因要求而变得复杂 对于眼球偏斜的幅度和方向的时刻变化 作为当前观看位置和航向方向的函数。这项研究 TVOR及其与上下文相关的性能因此具有广泛的相关性 研究成功的基本中枢神经系统策略 反身性和自主性运动行为的整合。建议的目标是 该项目的目的是确定策略和负责 前庭信号在TVOR中的动态变换，使用 将双目眼球运动记录与 单单位电生理学和计算建模研究。这项研究将 重点研究携带多种脑干神经的脑干神经元的特征 翻译过程中的头部和眼睛运动信号。实验数据将是 在之前的建模调查和理论研究的背景下进行评估 将根据需要延长和修改工作，以纳入新的调查结果。

DESCRIPTION (provided by applicant): The vestibulo-ocular reflexes (VORs) play an essential role as part of an integrated gaze control system to ensure stable perception of the environment during movement. While the rotational VOR (RVOR) has been well characterized at both behavioral and neurophysiological levels, the neural circuitry and computations underlying the translational VOR (TVOR) are less well understood. Despite similar functional goals, distinct temporal properties of the reflexes at both sensory and motor levels imply a requirement for different dynamic processing of canal and otolith signals. Furthermore, appropriate reflex behavior during translation is complicated by the requirement for moment-to-moment changes in the amplitude and direction of ocular deviations as a function of both current viewing location and heading direction. The study of the TVOR and its context-dependent performance thus has broad relevance in investigating basic central nervous system strategies for the successful integration of reflexive and voluntary motor behaviors. The goal of the proposed project is to identify both the strategy and the neural elements responsible for the dynamic transformation of vestibular signals in the TVOR, using an interdisciplinary approach that combines binocular eye movement recordings with single unit electrophysiology and computational modeling studies. The study will focus on the characterization of brainstem neurons that carry combinations of head and eye movement signals during translation. Experimental data will be evaluated in the context of previous modeling investigations and theoretical work will be extended and modified as required to incorporate new findings.