Nutritional Biochemistry and Epidemiology of Cancer

描述(申请人提供)：这是唯一一个专门关注营养和癌症的培训项目的第一次更新，该培训项目最初是在1997年资助的。虽然它享有相当大的内部支持，并被认为是癌症研究的主要希望，但NCI的外部资金相对较少集中在营养和癌症领域。营养研究非常引人注目，但也涉及极其复杂的研究设计，充满了测量误差、潜在的偏差，并因饮食成分和模式之间的相互关系而变得复杂。需要强有力的培训方案，以招募最好的科学家进入这一领域，并在发展推动科学和将新技术纳入该领域所需的能力方面提供支持。 我们设计了一项培训计划，以满足我们的研究界对训练有素、方法复杂的科学家的需求，他们愿意通过招募优秀科学家到该领域并在营养生物化学、营养流行病学和癌症研究方法方面进行交叉培训，将他们的研究生涯集中在营养和癌症上。为了让研究员为营养和癌症研究的职业生涯做好准备，该计划有四个具体的目标或培训目标。在多学科培训咨询委员会和导师团队的指导下，研究员将学习与致癌的营养研究相关的基本生物化学和流行病学，掌握该领域的核心研究方法；在特定主题领域进行研究，以加深我们对饮食和癌症的知识，并进行专业发展，以便他们能够成功地成为具有道德动机的、富有成效的研究人员，走向该领域的学术生涯。为此，我们每年需要两个博士后和六个博士后实习生职位。

DESCRIPTION (provided by applicant): This is the first renewal of the only training program focusing exclusively on nutrition and cancer that was originally funded in 1997. Although it enjoys considerable intramural support, and is recognized as a major promising of cancer research, relatively little of NCI external funding is focused on the area of nutrition and cancer. Nutritional research is very compelling but also involves study designs that are extremely complex, fraught with measurement error, potential biases and is complicated by interrelations among dietary components and patterns. Strong training programs are needed to recruit the best scientists into this area and to provide support in developing the competencies needed to advance the science and incorporate new technologies into the field. We have designed a training program to meet the need of our research community for well-trained and methodologically sophisticated scientists willing to focus their research careers on nutrition and cancer through recruitment of excellent scientists to the field and cross training them in nutritional biochemistry, nutritional epidemiology, and cancer research methods. To prepare fellows for careers in nutritional and cancer research, the program has four specific aims or training objectives. Under the direction of a multidisciplinary Training Advisory Committee and preceptor team, fellows will learn the fundamental biochemistry and epidemiology relevant to nutritional research on carcinogenesis, become competent in research methods central to this field; conduct research in a specific topic area that will further our knowledge of diet and cancer and develop professionally so they can succeed as ethically motivated, productive researchers heading towards academic careers in this field. We are requesting two postdoctoral and six predoctoral trainee positions each year for this purpose.