Structural Studies of Pestivirus Envelope Glycoproteins

害虫病毒引起一系列症状，从神经症状到胎儿在宫内或出生后不久的丧失。这对经济产生了重大影响，因为受这些病毒影响的主要动物是猪、牛和羊等牲畜。目前，细胞进入的机制尚不清楚，并被认为与其他病毒不同。了解细胞进入的机制可以进行有针对性的治疗，因为阻止细胞进入可以防止感染。该项目旨在通过对负责细胞进入的蛋白质的结构研究来研究这种进入机制。这些结构研究将得到显微镜和生化实验的补充，这些实验研究这些蛋白质是如何相互作用的。

Pestiviruses cause a wide range of symptoms from neural symptoms to loss of foetuses in utero or shortly after birth. This had a significant economic impact as the main animals affected by these viruses are livestock such as pigs, cows, and sheep. Currently the mechanism of cell entry is unknown and thought to be different from other viruses. Understanding the mechanism of cell entry could enable a targeted treatment as blocking cell entry would prevent infection. This project aims to investigate this entry mechanism through structural studies of the proteins known to be responsible for cell entry. These structural studies will be complimented by microscopy and biochemical experiments investigating how these proteins interact with each other.AfS, ENWW