BIOLOGICAL BASES OF DRUG SEEKING BEHAVIOR

描述：(申请人提供) 这一博士后和博士后培训计划支持 能够在以下级别进行临床前研究的专家 从分子到行为对潜在的生物学机制的影响 发展、维持和消除寻毒行为。三十一岁 俄勒冈健康科学大学研究生教职员工 作为博士后研究员和博士生的导师 进入基础科学研究生课程，学习行为神经科学， 神经科学、生理学和药理学，或细胞生物学。主要研究 区域代表三个层次。一些教职员工主要在 细胞/分子水平，使用分子生物学、电生理和 电子显微镜技术。其他教员的工作主要是在 生理、生化和药物系统，使用受体结合， 放射自显影、体内微渗析和伏安法以及电生理 技巧。最后，其他教员主要从事行为学方面的工作 药理学、认知神经科学和药物遗传学，使用行为学 测试，静脉药物自我给药，数量遗传学和 基因图谱，以及计算机建模技术。广袤的区域 现有的教师合作包括：多巴胺能系统的研究， 从分子生物学到行为学；对遗传学的广泛研究 药物反应的决定因素，从分子到统计的所有层面 基因图谱；研究获得性和未获得性反应的决定因素 对药物，特别是它们的奖励作用和药物自我给药。 敏感度、容忍度和依赖/退缩现象 包括酒精在内的各类滥用药物正在积极调查中。 培训包括扎实的基础科学基础，特别是 关于滥用药物的药理学培训，并广泛和持续 参与研究。

DESCRIPTION: (provided by applicant) This program for pre- and postdoctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the behavioral on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Thirty-one members of the graduate faculty of the Oregon Health Sciences University serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or cell biology. Major research areas represent three levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, electrophysiological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and elecrophysiological techniques. Finally, other faculty work primarily in behavioral pharmacology,cognitive neuroscience, and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modelling techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self-administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse including alcohol are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research.