OBSERVER PERFORMANCE STUDIES-READER SELECTION & TRAINING

描述(改编自申请者摘要)：许多调查 现在在成像系统的评估和比较期间进行 包括对正常和异常情况的解释(阅读)研究， 通过接收器工作特性(ROC)或其导数进行评估。 不幸的是，如果考虑到案例和读者的代表性， 大多数研究都需要大得令人望而却步的样本量和数量 以便为统计提供足够的统计能力 读取节点之间的显著区分，其方式既 具有临床相关性并可推广。案例和观察者的方法 这一领域的这些研究的选择方案在很大程度上是武断的 (而且往往不是最优的)。申请者建议调查 具体案例的实施和读者选择的可能性 方案可以让人们专注于有限的临床问题，这些问题可能是 通过观察者性能研究得出了结论，同时需要 很小的努力；因此，使这种研究更加可行和合理，以 表演。在之前的努力中，申请者报告说他们专注于 关于案例选择问题的调查。虽然他们提议继续 在这方面调查几个方面，目前的提案将侧重于 观察者(读者)的选择和培训对学习的可能影响 设计和结果。

DESCRIPTION (Adapted from Applicant's Abstract): Many of the investigations that are now carried out during imaging systems' evaluations and comparisons include interpretation (reading) studies of normal and abnormal cases that are evaluated by receiver operating characteristics (ROC) or derivatives thereof. Unfortunately, if one takes into account case and reader representativeness, most studies would require prohibitively large sample sizes and a large number of readers in order to produce adequate statistical power for a statistically significant discrimination between reading nodes in a manner that is both clinically relevant and generalizable. Approaches to case and observer selection protocols for these studies in this field have been largely arbitrary (and frequently suboptimal). The applicants propose to investigate the possibility that the implementation of specific case and reader selection protocols could allow one to focus on limited clinical questions that can be conclusively answered with an observer performance study while requiring a small effort; hence, making such studies much more feasible and reasonable to perform. During the prior effort, the applicants reported focusing their investigation on case selection issues. While they proposed to continue to investigate several aspects in this regard, the current proposal would focus on the possible effects of observer (reader) selection and training on study design and results.