Elucidation of the Genetic Mechanisms of Primary Aldosteronism: The Most Common, Curable Form of Hypertension

高血压是影响10-40%人口的主要心血管危险因素。类固醇激素醛固酮控制血压，在高血压中起重要作用。原发性醛固酮增多症（PAL）是一种由醛固酮过量产生引起的疾病，是最常见的、可治愈的高血压形式。我将确定负责PAL的分子机制，以推进新诊断工具的开发和新治疗靶点的确定。

Hypertension is a major cardiovascular risk factor that affects 10-40% of the population. The steroid hormone aldosterone controls blood pressure and plays a significant role in hypertension. Primary Aldosteronism (PAL), a condition caused by the excessive production of aldosterone, is the most common, curable form of hypertension. I will identify the molecular mechanisms responsible for PAL, to advance the development of new diagnostic tools and identification of novel therapeutic targets.