Investigation on friction between cardiovascular medical devices and arterial tissue

目前，关于心血管医疗设备（如支架和导管）之间的摩擦以及动脉对它们的反应的研究非常有限。此外，人们对潜在的摩擦机制知之甚少。这个项目是关于在体外环境中生成可靠的摩擦数据。为此，内皮细胞（覆盖动脉内部的细胞）将在基质上培养并进行摩擦学测试。将研究细胞损伤和细胞反应（变形、基因表达），以了解细胞对摩擦的反应。目的和目的：确定心血管医疗器械材料与内皮细胞之间的摩擦系数。研究内皮细胞与材料之间潜在的摩擦机制。研究细胞在摩擦下对不同物质的反应。应用和好处：更好地了解细胞-材料相互作用和摩擦机制可以用于开发更好的材料和涂层。由于有可靠的摩擦数据，可以对医疗设备进行改进的模拟。该博士项目符合EPSRC医疗保健技术的研究领域。

Currently, very limited research has been carried out on the friction between cardiovascular medical devices such as stents and catheters and how arteries react to them. Also, little is known about the underlying friction mechanisms.This project is about generating reliable friction data in an in vitro environment. For this, endothelial cells (the cells covering the inside of arteries) will be cultured on a substrate and tribologically tested. Cell damage and reactions of the cells (deformation, gene expressions) will be investigated to find out how the cells react to the friction.Aims and Objectives:Determine friction coefficients between cardiovascular medical device materials and endothelial cells.Study the underlying friction mechanisms between endothelial cells and materials.Investigate the cells reactions to different materials under friction.Applications and benefits:Better understanding of cell-material interactions and friction mechanisms can be used to develop better materials and coatings.Improved simulations of medical devices can be carried out due to reliable friction data.This PhD project fits into the research area of Healthcare Technologies of the EPSRC.