Oncogenic Human Papillomaviruses & Prostate Cancer Risk

前列腺癌是男性最常见的癌症原因，但这种疾病的风险因素很少被确定。一些先前的研究表明，性行为和相关的暴露于性传播媒介增加风险，特别是性伴侣的数量，首次性交的年龄，性频率，淋病和梅毒的历史，梅毒和人乳头瘤病毒（HPV）的致癌亚型的血清学证据与前列腺癌的风险有关，但结果尚未得到证实。在最近一项关于65岁以下男性前列腺癌风险因素的研究中，我们发现随着女性性伴侣数量的增加，风险显著增加（趋势p <0.001），我们假设这与先前暴露于I-IPV-16或-18有关。为了验证这一假设，我们提出了一项基于人群的病例对照研究，该研究将分析1993-1996年诊断的经组织学证实的前列腺癌病例（n=648）和对照组男性（n = 571）的血清，其中前列腺癌病例由西雅图-普吉特海湾SEER登记处确定，对照组男性无前列腺癌病史，且频率与癌症病例的年龄相匹配。病毒样颗粒ELISA血清学试验将用于检测BPV-16和-18。关于前列腺癌已知和疑似风险因素的详细数据将通过面对面访谈获得。非条件logistic回归将用于估计与HPV- 16/-18感染相关的相对风险，控制潜在的混杂因素。前列腺癌病例的临床数据将用于评估与HPV的相关性是否根据疾病的侵袭性而不同。这项研究的结果将提供关于这些致癌HPV亚型是否在前列腺癌病因学中发挥作用的见解。如果存在关联，则结果将具有重要的公共卫生意义，因为暴露和疾病都很常见。

Prostate cancer is the most frequent cause of cancer in men, yet few risk factors for this disease have been identified. Some prior studies suggest that sexual behavior and associated exposure to sexually transmitted agents enhance risk In particular, number of sexual partners, age at first intercourse, sexual frequency, history of gonorrhea and syphilis, and serologic evidence of syphilis and oncogenic subtypes of human papillomavirus (HPV) have been associated with risk of prostate cancer, but results have not been confirmed. In a recent study of risk factors for prostate cancer in men under age 65 years, we found a significant increase in risk with increasing number of female sexual partners (trend p <0.001), which we hypothesize is related to prior exposure to I-IPV-16 or -18. To test this hypothesis, we propose a population-based case-control study that will analyze stored serum from histologically confirmed prostate cancer cases (n=648) diagnosed during 1993-1996 and ascertained by the Seattle-Puget Sound SEER registry and from control men (n--571) without a history of prostate cancer and frequency matched on age to cancer cases. Virus-like particle ELISA serologic assays will be used to detect BPV-16 and -18. Detailed data on known and suspected risk factors for prostate cancer will be available from in-person interviews. Unconditional logistic regression will be used to estimate relative risks associated with HPV- 16/-18 infection, controlling for potential confounding factors. Clinical data on prostate cancer cases will be utilized to assess whether associations with HPV differ according to disease aggressiveness. Results from this study will provide insight on whether or not these oncogenic HPV subtypes play a role in prostate cancer etiology. If there is an association, the results will have important public health implications since both the exposure and the disease are common.