DIET AND GENETIC RISKS FOR LUNG CANCER

描述：(申请人的描述)这项建议是为了进行调查 饮食之间的联系，以及饮食和遗传的相互作用 基因多态，有患肺癌的风险。数据来自18,314名男性和 参加β-胡萝卜素和视黄醇化学预防试验的女性 (Caret)。经过平均7.4年的跟踪，Caret拥有关于 近800例肺癌病例。饮食摄入量是用食物来衡量的 频次问卷调查。血清微量营养素和遗传多态有 对388例肺癌患者和753例对照进行了分析。我们的具体目标 包括： 1.为了更好地了解水果和蔬菜的摄入量与 降低患肺癌的风险。水果和蔬菜的摄入量将以下列方式衡量： (I)每天的供应量(总量并按植物化学物质含量分组)，(Ii) 与水果和蔬菜有关的微量营养素，包括维生素C和 E、叶酸和类胡萝卜素，以及(Iii)血清类胡萝卜素和维生素E。 2.研究水果和蔬菜摄入量与肺的关系 致癌风险受致癌物质代谢酶基因类型的影响 (即，CYP2D6、CYP2EL、CYP1A1、GSTM1、GSTT1和EH)。我们将进行队列 实验室膳食摄入量资料分析及病例对照分析 基础研究。尽管已经收集了基线饮食数据，而且 实验室分析(血清微量营养素和基因类型) 完成后，没有具有营养专业知识的CARET调查人员 他们被资助进行这些分析，并撰写相关的 手稿。因此，为了满足上述提出的具体目标，我们要求 支持营养流行病学家、统计学家、分子生物学家、 以及发表调查结果所需的工作人员支持。这部作品的主题是 关于肺癌的病因和预防的重要问题，并可以 在已有资金的基础上，以适度的资金完成 投入了这项大规模的化学预防试验。

DESCRIPTION: (Applicant's Description) This proposal is for an investigation into the associations of diet, and interactions of diet and genetic polymorphisms, with the risk of lung cancer. Data are from 18,314 men and women enrolled in a chemoprevention trial of beta-carotene and retinol (CARET). After a mean of 7.4 years of follow up, CARET has endpoint data on almost 800 cases of lung cancer. Dietary intake was measured with a food frequency questionnaire. Serum micronutrient and genetic polymorphisms have been analyzed for 388 lung cancer cases and 753 controls. Our specific aims are: 1. To better understand the association of fruit and vegetable intake with the reduced risk of lung cancer. Fruit and vegetable intake will be measured as: (i) servings per day (total and grouped by phytochemical content), (ii) micronutrient associated with fruits and vegetables, including vitamins C and E, folate, and carotenoids, and (iii) serum carotenoids and vitamin E. 2. To examine whether the associations of fruit and vegetable intake with lung cancer risk are modified by genotypes of carcinogen metabolizing enzymes (i.e., CYP2D6, CYP2El, CYP1Al, GSTM1, GSTT1, and EH). We will conduct cohort analyses for dietary intake data and case control analyses for laboratory based studies. Although the baseline dietary data have been collected and the laboratory analyses (for serum micronutrients and genotypes) have been completed, there are no CARET investigators with expertise in nutrition science who are funded to conduct these analyses and write the associated manuscripts. Therefore, to meet the specific aims proposed above, we request support for nutritional epidemiologists, a statistician, molecular biologist, and the staff support needed to publish the findings. This work addresses important questions about the etiology and prevention of lung cancer, and can be completed with a modest amount of funding in addition to what has already been invested in this large chemoprevention trial.