THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY

在这个提议中要检验的假设是，缺血后免疫 反应会导致脑损伤，而脑损伤可以通过以下方式减少 适当地调节免疫反应。缺血发作后不久 中风时，淋巴细胞浸润大脑，引发免疫反应 对抗大脑抗原采用短暂性中脑缺血动物模型， 动脉闭塞，我们将定义缺血后免疫的性质， 并探索操纵这种反应以获得治疗益处的方法。 该项目的具体目标是：1）确定缺血时间间隔 中风发作和发展的细胞免疫反应， 脑抗原，并分析该反应，2）以确定性质， 中风后淋巴细胞向脑内浸润的时间过程，以及3） 确定调节缺血后细胞凋亡的治疗潜力， 免疫反应

The hypotheses to be tested in this proposal are that the post-ischemic immune response contributes to brain injury and that brain injury can be reduced by appropriately modulating the immune response. Soon after the onset of ischemic stroke, lymphocytes infiltrate the brain and an immune response is triggered against brain antigens. Using an animal model of transient middle cerebral artery occlusion, we will define the nature of the post-ischemic immune response and explore ways to manipulate that response for therapeutic benefit. The specific aims of the project are: 1) to determine the time between ischemic stroke onset and development of a cellular immune response directed towards brain antigens, and to analyze that response, 2) to determine the nature and time course of lymphocyte infiltration into brain after stroke, and 3) to define the therapeutic potential of modulating the post-ischemic cellular immune response.