Enhancing protective efficacy of avian influenza vaccines through targeted delivery of protective antigens to chicken immune cells

禽流感病毒（AIV）是造成世界各地家禽生产系统严重经济损失的原因。在过去几年中，高致病性禽流感（HPAI）病毒的爆发对世界各地数百万农业和相关社区的贸易、粮食安全、公共卫生和生计产生了负面影响。疫苗接种是控制禽流感流行的关键措施之一。为此，我们需要高效的疫苗。这个博士项目提出开发新的疫苗，在鸡中引起快速，强烈和持久的体液和细胞免疫反应，以对抗AIV。我们将探索新出现的疫苗学方法的各个领域，例如使用选择性和靶向的抗原原位递送到抗原呈递细胞（APC），病毒载体和基于纳米颗粒的疫苗递送系统。这项拟议的博士研究将为改进家禽中的AIV疫苗提供平台。拥有这种新型、高度保护性和具有成本效益的疾病控制工具和策略将有助于最大限度地减少传染病对养殖动物的影响，并在全球范围内提供经济、公共卫生、环境和社会效益。AfS，ENWW

Avian influenza viruses (AIVs) are responsible for severe economic losses in poultry production systems throughout the world. Over the past few years, outbreaks of highly pathogenic avian influenza (HPAI) viruses have negatively affected the trade, food security, public health and livelihood of millions of farming and associated communities all around the world. Vaccination is one of the key ways of controlling AIV prevalence in poultry. For this, we need highly effective vaccines. This PhD project proposes to develop new vaccines that elicit rapid, strong and durable humoral and cellular immune responses in chickens against AIV. We will explore various areas of new emerging vaccinology approaches like the use of selective and targeted in situ delivery of antigens to antigen presenting cells (APCs), viral vectors and nanoparticle-based vaccine delivery systems.This proposed PhD research will provide a platform for the improvement of vaccines against AIV in poultry. Having such novel, highly protective and cost-effective disease control tools and strategies will help to minimise the impact of infectious diseases on farmed animals and offer economic, public health, environmental and social benefits globally. AfS, ENWW