Endogenous opioids in the amygdala.

令人衰弱的焦虑症，如创伤后应激障碍或恐慌症，影响着14%的澳大利亚成年人，目前的治疗方法往往无效。杏仁核是大脑中学习恐惧反应的关键区域，也是减少我们恐惧反应的关键。该项目将确定大脑自身的内源性阿片类药物是否可以改变杏仁核的活动，以便为提高疗效的新药物疗法提供新的线索。

Debilitating anxiety disorders, such as post-traumatic stress disorder or panic disorder, affect 14% of adult Australians and current therapy is often ineffective. The amygdala is a brain region that is key to learning fear responses but also in reducing our fear responses. This project will determine whether the brain’s own endogenous opioids can modify the activity of the amygdala in order to provide new leads for novel pharmacotherapies with enhanced efficacy.