STAGE MATCHED INTERVENTION TO INCREASE DUAL METHOD USE

防止性传播感染(STI)，人类 免疫缺陷病毒(HIV)和意外怀孕可以实现 使用双重避孕方法。这项建议是 旨在开发、实施和评估 创新、计算机辅助、基于舞台的个性化交互 基于跨理论的干预(个体化干预) 模式与增强型标准护理咨询中双重使用的比较 避孕方法。400例高血压病患者的随机临床试验 风险女性将评估行为和生物方面的主要结果。女人 将每隔6个月跟踪调查24个月，并进行后续调查 访谈以确定报告的双重避孕方法的使用情况 (行为结果)。12个月和24个月的临床检查和 随着新症状的出现将评估生物学结果，包括 性传播感染和意外怀孕的事件或复发病例。次要的 结果将包括中间结果变量，如变化 在变化的阶段，变化的过程，决策的平衡，和自我 功效。这项研究的主要假设是：1. 个性化干预将导致双重避孕措施的增加 使用；2.个体化干预将带来保护 防止性传播感染的新病例，再次感染 生物体和计划外怀孕；以及3.个体化 干预将导致次要结果的最大变化 措施。初步结果之间的比较将根据 使用事件发生时间(生存)曲线的意向治疗原则 用Kaplan-Meier非参数估计和对数秩作分析 统计数据。如果被发现是有效的，阶段匹配的干预措施已经 有可能在学校、诊所、办公室和 防止性传播感染/艾滋病毒和意外怀孕的社区中心。

Protection from both sexually transmitted infections (STIs), human immunodeficiency virus (HIV), and unintended pregnancy can be achieved with the use of dual methods of contraception. This proposal is designed to develop, implement, and evaluate the impact of an innovative, computer-assisted stage-based individualized interactive intervention (Individualized Intervention) based on the transtheoretical model compared to enhanced standard care counseling on the use of dual methods of contraception. This randomized clinical trial of 400 high- risk women will assess behavioral and biological primary outcomes. Women will be followed at 6 month intervals for 24 months with follow-up interviews to determine reported use of dual methods of contraception (behavioral outcome). Clinical examinations at 12 and 24 months and with new onset of symptoms will assess biological outcomes including incident or recurrent cases of STI and unintended pregnancy. Secondary outcomes will include intermediate outcomes variables such as changes in stage of change, processes of change, decisional balance, and self- efficacy. The primary hypotheses of this study are: 1. the Individualized Intervention will result in increased dual contraceptive use; 2. the Individualized Intervention will result in protection against new cases of STIs, reinfection with sexually transmitted organisms, and unplanned pregnancies; and 3. the Individualized Intervention will lead to the greatest changes in secondary outcome measures. Comparisons among the primary outcomes will be made according to the intention-to-treat principle using time to event (survival) curve analysis with the Kaplan-Meier nonparametric estimator and the log rank statistic. If found to be effective, the stage-matched intervention has potential for widespread dissemination in schools, clinics, offices, and community centers to prevent STIs/HIV and unintended pregnancy.