CORE--Cellular responses to DNA damage

描述：研究核心2是由一组优秀的 诱变和DNA修复领域的研究人员。其中包括7 正式会员和两个二级会员以及一个附属会员。的主要目的 这一核心是协调研究，以了解影响 致癌物诱导的DNA损伤的形成，这种损伤的修复 (e.g., NER，碱基切除修复，重组修复），以及特异性 细胞对DNA损伤的反应。这应该提供一个洞察力， 致癌机制和其他过程，如细胞凋亡， 暴露于环境化学品。这有五个具体目标 研究核心：1）保持和扩大知识氛围， 促进更多的信息共享，培养科学发展， 联系成员，并涉及非中心科学家。2)加强和 扩大合作，以促进未来的计划项目赠款。3)推广新 合作解决与环境健康有关的问题。4)到 协调理解遗传差异在人类遗传学中的作用， 对DNA损伤的反应，包括毒性作用的机制。5)到 扩展蛋白质和DNA分析的分析技术列表 损害赔偿，无论是在损害赔偿的类型和敏感性， 侦测

Description: Research core 2 is comprised of a group of outstanding investigators in the area of mutagenesis and DNA repair. It includes seven full and two secondary members and one affiliate. The primary objective of this core is to coordinate research toward understanding the factors affecting the formation of carcinogen-induced DNA damages, the repair of such damages (e.g., NER, base excision repair, recombinational repair), and the specific responses of cells to DNA damage. This should provide an insight into the mechanism of carcinogenesis and other processes such as apoptosis from exposure to environmental chemicals. There are five specific aims of this research core: 1) To maintain and expand an intellectual atmosphere that fosters increased sharing of information, nurtures the scientific growth of associate members, and involve non-Center scientists. 2) To strengthen and expand collaborations toward future program project grants. 3) To promote new collaborations to address problems related to environmental health. 4) To coordinate the understanding of the role of genetic differences in the response to DNA damage, including the mechanism of toxic effects. 5) To expand the list of analytical techniques for the analysis of protein and DNA damages, both in terms of the types of damages and in the sensitivity of detection.