CORE--BIOTRANSFORMATION AND TOXICITY OF ENVIRONMENTAL CHEMICALS

生物转化和毒性的总体目标 环境化学品研究的核心是调查对环境的影响 环境因素对化学毒性的生物转化研究 环境化学品，异源代谢酶的调节， 确定毒性和致癌的分子机制，并 识别天然化学保护剂并表征其对 细胞过程。 环境化学物质的生物转化与毒性研究核心 该中心成立于1994年，是该中心重组后成立的。当时， 核心进行了重组，并将该核心的监督交给了CS Yang博士。 1996年，保罗·托马斯博士被选为联席主任，因为杨博士 成为该中心的副主任。核心成员的研究兴趣 分为五个一般的工作领域，分别是外源生物的调节和 环境化学品的类固醇新陈代谢(康尼和兰伯特博士)， 异源酶(Hong博士和Iba博士)、脑的遗传多态性 化学品和类固醇激素的新陈代谢(Lowndes和Thomas博士) 致癌和毒性的分子机制(陈和伟博士)和 饮食成分对致癌和毒性的保护， (杨博士和康尼博士)。 这个核心的未来目标是进行更深入的机制研究 了解化学物质的新陈代谢如何影响其毒性； 外源代谢酶是如何受环境化学物质调节的， 饮食化学物质和激素；扩大对动物组织的研究 和蛋白质传递给人类；并扩大他们的基因研究，以了解 环境化学物质会改变基因和基因表达。本研究的核心是 将推动进一步的合作调查和项目 该中心的研究人员。未来的具体研究包括其他 环境化学物质在不同环境中的P450酶代谢研究 动物和人类组织；识别与 不同环境化学物质的新陈代谢；外源生物的特征 人体肺、食道和肝脏中的代谢酶；检查其影响 吸烟和过氧化体增殖物对雌二醇代谢的影响； 对P450 2E1和其他异源生物进行额外的结构-功能研究 代谢酶；研究CYP 3A表达的调节；执行 阿司匹林化学保护作用的药代动力学和药效学研究 不同的食品化学物质；检测P53基因在致癌物诱导中的作用 肿瘤；并使用转基因动物模型研究环境的影响 毒剂和氧化应激对肿瘤形成和预防的影响。

The general goals of the Biotransformation and Toxicity of Environmental Chemicals Research Core are to investigate the impact of environmental factors on chemical toxicity by examining biotransformation of environmental chemicals, the regulation of xenobiotic metabolizing enzymes, identification of molecular mechanisms of toxicity and carcinogenesis, and to identify natural chemoprotective agents and characterize their effects on cellular processes. The Biotransformation and Toxicity of Environmental Chemicals Research Core was formed in 1994 following reorganization of the Center. At that time, the Core was restructured and supervision of this core was given to Dr. CS Yang. In 1996, Dr. Paul Thomas was selected to serve as Co-Director because Dr. Yang became Deputy Director of the Center. The research interests of Core members fall into five general working areas which are Modulation of xenobiotic and steroid metabolism by environmental chemicals (by Drs. Conney and Lambert), Genetic polymorphisms of xenobiotic enzymes (Drs. Hong and Iba), Brain metabolism of chemicals and steroid hormones (Drs. Lowndes and Thomas), Molecular mechanisms of carcinogenesis and toxicity (Dr. Chen and Wei) and Protection against carcinogenesis and toxicity by dietary constituents, (Dr. Yang and Conney). Future goals of this core are to conduct greater in-depth mechanistic studies to understand how metabolism of chemicals affect its toxicity; to understand how xenobiotic metabolizing enzymes are regulated by environmental chemicals, dietary chemicals, and hormones; to extend investigations from animal tissues and proteins to humans; and to expand their genetic studies to understand how environmental chemicals alter genes and gene expression. This research core will promote further collaborative investigations and projects among researchers of the Center. Specific future studies include additional metabolism studies of environmental chemicals by P450 enzymes in different animal and human tissues; identify genetic polymorphisms associated with the metabolism of different environmental chemicals; characterize the xenobiotic metabolizing enzymes in human lung, esophagus, and liver; examine the effects of cigarette smoking and peroxisome proliferators on estradiol metabolism; perform additional structure-function studies on P450 2E1 and other xenobiotic metabolizing enzymes; study the regulation of CYP 3A expression; perform pharmacokinetic and pharmacodynamic studies on the chemoprotective effects of different food chemicals; examine the role of p53 gene in carcinogen-induced tumors; and use transgenic animal models to study the effects of environmental agents and oxidative stress on tumor formation and prevention.