CORE--CELL BIOLOGY AND IMMUNOTOXICOLOGY

描述：细胞生物学和免疫毒理学研究核心作为 以生物为导向的化学/分析核心的补充 OSUEHS中心提供与人类健康相关的应用重点 可利用的化学和物理方法和专业知识 其他核心。因此，核心为启动研究提供了一个媒介。 项目的方向，否则可能不会被追求。堆芯 领导层已经从巴恩斯博士(1997年离开俄亥俄州立大学)改为莱德博士。 贝恩博士、科克夫利特博士和里德博士继续留在这个核心，并加入了 最近的中心调查人员：格林伍德、黑根、伊什梅尔和贝拉。 Hedstrom博士(中心准成员)也与此有关 研究核心。此外，还有博士后2人，研究生17人 和12名研究助理。此核心的目标是提供 智力资源，用于研究细胞信号和 激素/细胞因子对生长、分化、早期发育和 细胞死亡的机制。这个核心的调查人员的具体项目 包括：分析T细胞的TCDD或Ah受体和 过氧化物体增殖物；外源生物的免疫调节；氧化应激， 包括线粒体功能障碍、谷胱甘肽和蛋白质硫醇，以及 关于细胞死亡和免疫毒性；与年龄有关的线粒体效应 功能。这个核心是以生物为导向的补充 化学/分析核心提供“与人类健康相关的焦点” 化学和物理方法的应用“。该核心协助 自1995年以来发表了97份出版物，其中约16份是合作研究。八 列出了过去的合作项目[Kerkvliet博士(4)；Barnes博士(2)； Reed博士(1)；Leid博士(1)]。未来的计划包括额外的联合 与较新的中心调查人员合作的项目，例如 Ishmael博士和Leid博士(克隆标准。α转录共激活因子)； Kerkvliet和Ishmael博士(评估细胞周期的新细胞培养模型 在接触非遗传毒性致癌物后)；里德博士和黑根博士在 谷胱甘肽、铁和维生素E对心肌细胞的影响 谷胱甘肽和维生素E在淋巴细胞凋亡中的作用； Kerkvliet、Vella、Leid和Hedstrom博士(TCDD对树突状细胞的影响)。 Kerkvliet博士和Vella博士将为此提供免疫学专业知识 核心，莱德和里德博士提供生化和分子方面的专业知识。 这个核心提供了与其他核心和中心的生物学桥梁 通过研讨会支持实验设计的研究人员 每月一次的实验室会议。

Description: The Cell Biology and Immunotoxicology Research Core serves as a biologically oriented complement to the Chemical/Analytical Cores of the OSUEHS Center to provide a focus of relevance to human health for application of the chemical and physical approaches and expertise available within the other Cores. Thus the Core provides a medium for the initiation of research projects in directions that otherwise may not have been pursued. Core leadership has changed from Dr. Barnes (who left OSU in 1997) to Dr. Leid. Drs. Bayne, Kerkvliet and Reed continue to be in this Core and are joined by recent Center investigators: Drs. Greenwood, Hagen, Ishmael and Vella. Dr. Hedstrom (Associate member of Center) also remains associated with this research core. In addition, there are 2 postdoctoral, 17 graduate students and 12 research assistants. The objectives of this Core are to provide an intellectual resource for pursuits into cellular signaling and hormonal/cytokine control of growth, differentiation, early development and mechanisms of cell death. Specific projects by investigators of this Core include: analysis of T cells with regard to TCDD or Ah receptor and peroxisome proliferators; immunomodulation by xenobiotics; oxidative stress, including mitochondrial dysfunction, glutathione and protein thiols, with regard to cell death and immunotoxicity; age-related effects on mitochondrial functions. This Core serves as a biologically oriented complement to the Chemical/Analytical Cores to provide "a focus of relevance to human health for application of chemical and physical approaches". This Core has assisted with 97 publications since 1995 with about 16 being collaborative studies. Eight past collaborative projects are listed [Dr. Kerkvliet (4); Dr. Barnes (2); Dr. Reed (1);and Dr. Leid (1)]. Future plans include additional joint projects with the more recent Center investigators, e.g., projects between Drs. Ishmael and Leid (cloning PAR. alpha transcriptional coactivators); Drs. Kerkvliet and Ishmael (new cell cultures models to assess cell cycle after exposure to nongenotoxic carcinogens); Drs. Reed and Hagen role of glutathione, iron and vitamin E on myocytes; Drs. Kerkvliet, Reed and Hagen (role of glutathione and vitamin E in apoptosis of lymphocytes); Drs. Kerkvliet, Vella, Leid and Hedstrom (TCDD effects on dendritic cells). Drs. Kerkvliet and Vella will provide the immunological expertise for this Core with Drs. Leid and Reed providing biochemical and molecular expertise. This Core provides biological bridging with the other Cores and Center investigators with support for experimental design fostered through workshops and monthly laboratory meetings.