ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVE

本申请是为了回应RFA AA-99-003而提交的， 五年的支持，研究的后果和机制， 成年和青少年双胞胎中的青少年酒精滥用。 研究 这项建议是在芬兰进行的两项正在进行的双胞胎家庭研究的基础上提出的。 一 一项名为FinnTwin 16的研究已经确定了2,800对出生于1975-79年的双胞胎， 在1991-1995年，对他们及其父母进行了问卷调查， 双胞胎达到16岁;双胞胎的随访问卷评估是 是在十七岁和十八岁半的时候做的 我们提出第四份问卷评估， 所有这些芬兰双胞胎，在22-25岁，以评估他们的成人使用/滥用 酒精与他们的社会、教育、职业和人际关系 能力。 根据青少年问卷评估，我们有 确定了>200双卵双胞胎对进行密集随访;目标共同 双胞胎被选择为极端一致或极端不一致， 青少年酗酒 在22-25岁的时候，我们会采访他们， 酒精中毒遗传学半结构化评估（SSAGA），访问它们 进行神经心理学测试， 与ERP范式的功能。 这些同卵双胞胎的家庭内比较 青少年酒精滥用的不一致性将有力地测试其 后果 为了赞扬这种对早期成人后果的评价， 青少年饮酒问题，我们建议对两个出生队列进行深入研究 来自第二个正在进行的研究，FinnTwin 12; 485对双胞胎，出生于1986-87年， 选择该项目进行深入研究，其中50%的家庭成员 酗酒的风险。 在2000-01年，这对双胞胎将在14岁时， 采访了青少年SSAGA（与其他资金），并作为一部分， 在这个建议中，我们将在面试中附加一个丰富的神经心理学 测试电池和分析唾液中的睾酮和皮质醇。 共同，这些 神经生理学、神经心理学和神经内分泌研究， 芬兰的双胞胎，他们的风险相关数据已收集较早，将 提供了神经生物学机制和后果的精辟分析， 青春期酗酒

Submitted in response to RFA AA-99-003, this application requests five years' support to study consequences and mechanisms of adolescent alcohol abuse in adult and adolescent twin pairs. The research proposal builds on two ongoing twin-family studies conducted in Finland. One study, FinnTwin16, has ascertained 2,800 twin pairs, born 1975-79, and assessed them, and their parents, with questionnaires, in 1991-1995, as the twins reached age 16; follow-up questionnaire assessments of the twins were made at ages 17 and 18 1/2. We propose a fourth questionnaire assessment of all these Finnish twins, at ages 22-25, to evaluate their adult use/abuse of alcohol and their social, educational, occupational and interpersonal competencies. From the adolescent questionnaire assessments, we have identified >200 dizygotic twin pairs for intensive follow-up; the targeted co- twins were selected for extreme concordance or extreme discordance for adolescent alcohol abuse. At ages 22-25, we will interview them with the Semi-Structured Assessment for Genetics of Alcoholism (SSAGA), access them with a neuropsychological test battery and evaluate their electrophysiological function with ERP paradigms. These within-family comparisons of co-twins discordant for adolescent alcohol abuse will robustly test for its consequences. To compliment this appraisal of early adult consequences of adolescent problem drinking, we propose intensive study of two birth cohorts from a second on-going study, FinnTwin12; 485 twin pairs, born 1986-87, are selected for intensive study in that project with 50% at elevated familial risk for alcoholism. At age 14, in years 2000-01, these twin pairs will be interviewed with the adolescent SSAGA (with other funding), and as part of this proposal, we will append to the interview an enriched neuropsychological test battery and assay testosterone and cortisol from saliva. Jointly, these neurophysiological, neuropsychological, and neuroendocrine studies of targeted Finnish twins, for whom risk-relevant data have been collected earlier, will offer incisive analyses of neurobiological mechanisms and consequences of alcohol abuse in adolescence.