Functional Neuroanatomical Deficits in ADHD Families

描述（由申请人提供）：尽管有过多的神经心理学 基于家庭的研究表明， 多动症（ADHD）是一种基于神经生物学的疾病，研究试图 对ADHD的神经生物学本质的定义很少。如NIMH所述， 关于ADHD的共识发展会议，显然需要更多 用基本的研究技术来定义多动症拟定的研究将 利用ADHD儿童多模式治疗研究（MTA）样本招募 30对多动症的父母和孩子ADHD二人组将由ADHD儿童和他们的 多动症的父母。还将招募15个正常的二对体 不符合ADHD诊断标准的人使用磁性的体积图像 将对所有二联体进行共振成像（MRI）。此外，所有的二元组 将进行一系列神经心理学测试， 使用功能性MRI（fMRI）评估激活。ADHD亲子对 还将参加一项重复测量研究， 神经解剖学上的变化对兴奋剂药物的反应。大脑激活 将评估预先指定的感兴趣区域中的体积和量级。 组间比较将评价结构和功能 注意缺陷多动障碍和正常亲子间的神经解剖学差异。 组内分析将比较ADHD患者的功能激活变化 在安慰剂和活性药物治疗条件下。此外，亲子 神经心理学表现，神经解剖学和大脑的对应关系 将在两组二联体中检查激活。本申请是 将涉及五个站点的协作R01。参与者将被 从三个MTA站点招募：大学医学中心（DUMC），纽约 州立精神病研究所和加州大学伯克利分校。成像将在 康奈尔大学威尔医学院DUMC的相应成像部位 大学和斯坦福大学分别。

DESCRIPTION (provided by applicant): Despite a plethora of neuropsychological and family-based research suggesting that Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiologically-based disorder, studies attempting to define the neurobiological nature of ADHD have been few. As stated in the NIMH Consensus Development Conference on ADHD, there is a clear need to more basically define ADHD using basic research techniques. The proposed study will utilize the Multimodal Treatment Study of ADHD children (MTA) sample to recruit 30 ADHD parent-child dyads. ADHD dyads will consist of ADHD children and their concordantly-affected ADHD parents. Fifteen normal dyads will also be recruited who do not meet ADHD diagnostic criteria. Volumetric images using Magnetic Resonance Imaging (MRI) will be acquired on all dyads. In addition, all dyads will perform a series of neuropsychological tests while generic brain activation is assessed using functional MRI (fMRI). ADHD parent-child dyads will also participate in a repeated measures study examining functional neuroanatomical change in response to stimulant medication. Brain activation volumes and magnitudes in pre-specified regions of interest will be assessed. Between-group comparisons will evaluate structural and functional neuroanatomical differences between ADHD and normal parent-child dyads. Within-group analyses will compare ADHD patients' functional activation changes across placebo and active medication conditions. In addition, parent-child correspondences in neuropsychological performance, neuroanatomy, and brain activation will be examined within the two groups of dyads. This application is a collaborative R01 that will involve five sites. Participants will be recruited from three MTA sites: University Medical Center (DUMC), New York State Psychiatric Institute, and UC Berkeley. Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively.