Photochemical Approaches to Cyclobutane Functionalization and Cyclopropane Cascade Reactions

这个项目将研究小环体系的形成和进一步的反应。例如，马来酸酐衍生物将在与一系列炔的各种[2+2]环加成反应中进行研究。然后，这些环丁烯将作为支架进行研究，以便与UCB合作进一步完善药物发现文库。在一项相关研究中，氨基环丙烷衍生物将作为底物进行新的自由基环化级联反应，以产生一系列复杂的支架，作为可能的药物发现支架。

This project will investigate the formation and further reactions of small ring systems.For example maleic anhydride derivatives will be investigated in a variety of [2+2] cycloaddition reactions with a range of alkynes. These cyclobutenes will then be investigated as scaffolds for further elaboration as drug discovery libraries in collaboration with UCB. In a related study amino-cyclopropane derivatives will be investigated as substrates to undergo novel radical cyclisation cascade reactions to generate a range of complex scaffolds as possible drug discovery scaffolds.