Enantioselective Fluorescent Sensors and Applications

描述：（由申请人提供）本项目的目标是 开发荧光传感器，用于手性对映体选择性识别 有机化合物和药物分子。这些传感器将由 使用光学活性的联萘基手性分子和树枝状聚合物。作为 这些对映体选择性荧光传感器的应用， Schiff碱-Lewis酸催化剂的筛选 醛与TMSCN的反应。使用拟议的 对映选择性荧光传感器，预计将快速识别 高对映选择性催化剂在组合矩阵中，只有一个 或两次荧光测量。对映选择性荧光传感器将 也可用于高通量的高对映选择性的搜索， 可用的，环境友好的催化剂，用于其他几种不对称 反应.传感器的实用性将通过准备其刘易斯 酸络合物该化合物具有良好的配位能力和手性识别能力， 刘易斯酸络合物可以允许对映选择性荧光识别 其它手性有机分子如胺、氨基醇。醛类， 酮和杂环。

DESCRIPTION: (provided by applicant) The objective of this project is to develop fluorescent sensors for the enantioselective recognition of chiral organic compounds and drug molecules. These sensors will be constructed by using optically active binaphthyl-based chiral molecules and dendrimers. As an application of these enantioselective fluorescent sensors, a combinatorial screening of the Schiff base-Lewis acid catalysts for the asymmetric reaction of aldehydes with TMSCN is proposed. With the use of the proposed enantioselective fluorescent sensors, it is expected to quickly identify the highly enantioselective catalysts in the combinatorial matrixes with only one or two fluorescence measurements. The enantioselective fluorescent sensors will also be used for the high through-put search of highly enantioselective, easily available, and environmentally benign catalysts for several other asymmetric reactions. The utility of the sensors will be expanded by preparing their Lewis acid complexes. The good coordination and chiral recognition ability of the Lewis acid complexes may allow the enantioselective fluorescent recognition of other chiral organic molecules such as amines, amino alcohols. aldehydes, ketones, and heterocycles.