Hybrid Enzymatic-Heterogeneous Catalytic Systems for Fine Chemical Synthesis

酶催化加氢通常需要辅因子，如NADH作为氢供体。关于过程的可持续性，辅因子的再生是必不可少的。使用第二种酶的传统方法增加了系统和下游产品分离和纯化的复杂性。在这个项目中，将测试通过多相催化再生辅因子。与固定化酶的组合系统也将被检查。几种酶-非均相催化体系将被开发用于精细化学合成。

Enzymatic hydrogenation usually requires cofactors, e.g. NADH, as hydrogen donors. Regarding process sustainability, regeneration of cofactor is essential. Conventional methods using a second enzyme increase the complexity of the system and the downstream product separation and purification. In this project, regeneration of cofactor via heterogeneous catalysis will be tested. A combined system with immobilised enzyme will also be examined. Several enzymatic-heterogeneous catalytic systems will be developed to target fine chemical synthesis.