EFFECTS OF CHRONIC OZONE EXPOSURE ON LUNG FUNCTION

描述：(改编自《调查者摘要》) 美国人暴露在环境臭氧(O3)浓度中 与急性呼吸道健康影响有关；然而，对此知之甚少 关于长期接触此类物质对人类呼吸系统健康的影响 周围环境的浓度。非人灵长类动物长期暴露于高剂量 臭氧浓度与中心细胞的病理变化有关 与年轻香烟中观察到的变化相似的肺部区域 吸烟者。根据调查人员完成的试点研究，目前 一项研究验证了这一假设，即人类存在暴露-反应 环境臭氧慢性暴露量与测量指标的关系 反映人类中心细胞区域变化的肺功能 肺(FEF25-75)；这种关系不是通过测量更多的 近端气道功能(FEV1)。 加州大学伯克利分校一年级学生，年龄18-21岁，终身居住在 洛杉矶盆地(n=200，高臭氧)和旧金山湾区(n=100， 低臭氧)将被研究。终身接触环境中的臭氧将通过以下公式估算 调查人员开发的调查问卷和环境相结合的方法 O_3数据。肺功能将用最大呼气流量-容量进行评估 曲线。学生将在4-6个月的低环境臭氧暴露后进行研究 并在夏季接触臭氧2-3个月后立即进行。40名学生 (每个区域20个)，位于FEF25-75的上下尾部 分配将经历2次受控的臭氧暴露(季节性如上) 然后进行BAL/活检以评估不同指标之间的关系 炎症、损伤/修复和氧化剂导致损伤/修复和FEF25-75。 回归将被用来评估终身接触臭氧之间的关系 和肺功能，根据既往和家族呼吸系统病史、过敏反应进行调整 历史、家庭特征、接触环境烟草烟雾和 颗粒物空气污染和NO2。 这是首次对慢性肺炎的影响进行详细的流行病学研究。 根据个人对终身接触的估计，接触空气污染物 和受控曝光数据。这项研究测试了一种特定的毒理学模型 与慢性呼吸道疾病相关的人类，并探索 作用机制。

DESCRIPTION: (Adapted from the Investigator's Abstract) A large part of the U.S. population is exposed to ambient ozone (O3) concentrations that are associated with acute respiratory health effects; however, little is known about the effects on human respiratory health of long-term exposure to such ambient concentrations. Chronic exposure of non-human primates to high concentrations of O3 are associated with pathologic changes in the centriacinar region of the lung that are similar to changes observed in young cigarette smokers. Based on pilot studies completed by the investigators, the current study tests the hypothesis that, humans, there is an exposure-response relationship between the amount of chronic exposure to ambient O3 and measures of lung function that reflect changes in the centriacinar region of the human lung (FEF25-75); and this relationship is not seen with measures of more proximal airway function (FEV1). First-year UC Berkeley students, ages 18-21 yrs, who are lifelong residents of the Los Angles Basin (n=200, high O3) and the San Francisco Bay Area (n=100, low O3) will be studied. Lifetime exposure to ambient O3 will be estimated with methods developed by the investigators that combine questionnaire and ambient O3 data. Lung function will be assessed with maximum expiratory flow-volume curves. Students will be studied after 4-6 months of low ambient O3 exposure and immediately after 2-3 months of exposure to summertime O3. Forty students (20 from each area) who are at the upper and lower tails of the FEF25-75 distribution will undergo 2 controlled O3 exposures (seasonal as above) followed by BAL/biopsy to evaluate relationships between measures of inflammation, injury/repair and oxidant induce damage/repair and FEF25-75. Regression will be used to evaluate relationships between lifetime O3 exposure and lung function, adjusted for past and family respiratory history, allergy history, home characteristics, exposure to environmental tobacco smoke and particle air pollution and NO2. This is the first detailed epidemiologic study of the effects of chronic exposure to an air pollutant based on individual estimates of lifetime exposure and controlled exposure data. The study tests a specific toxicologic model in humans that has relevance for chronic respiratory disease and explores mechanisms of effects.