Vitamin K: vascular calcification and age-related bone *

描述(由申请人提供)： 维生素K可能在血管钙化的发病机制中发挥作用，因为 以及与年龄相关的骨质流失。流行病学证据表明 维生素K依赖蛋白与基质GLA蛋白(MGP)的关系 和血管钙化。维生素K营养的生化标志物有 除了低骨量外，还与血管钙化有关。 日常饮食中维生素K的摄入量很低。然而，目前还不清楚这些是否 维生素K营养指标是全面性营养不良的指标 在这些研究中的地位。此外，长期服用维生素K的影响 关于血管钙化的补充剂还没有被研究过。在一个 一项资助的为期3年的双盲安慰剂对照研究的辅助研究 补充维生素K对骨密度和骨量的影响 周转率，我们建议研究补充维生素K的效果(500 G/d)对450名老年男女血管钙化进程的影响 60-80岁，他们已经在接受骨质流失的监测。我们将衡量 电子束CT用于血管钙化的研究 (EBCT)在补充维生素K的3年开始和结束时。 此外，我们还将在1，6，12，24和 36个月的维生素K补充剂。其他协变量将是 作为资助研究的一部分，在研究过程中收集的数据包括 维生素K、维生素D和钙的生化标志物，骨的标志物 营业额、髋部骨密度、年龄、人体测量数据、体力活动、饮食 摄取、用药和吸烟。拟议的辅助试验提供了一个 确定维生素K补充剂是否会减少的独特机会 老年男性和女性血管钙化的进展。

DESCRIPTION (provided by applicant): Vitamin K may play a role in the pathogenesis of vascular calcification, as well as age-related bone loss. Epidemiological evidence has shown associations between the vitamin K-dependent protein, Matrix Gla Protein (MGP) and vascular calcification. Biochemical markers of vitamin K nutrition have been associated with vascular calcification, in addition to low bone mass. Usual dietary intakes of vitamin K are low. However, it is not known if these markers of vitamin K nutrition are indicators of generalized poor nutritional status in these studies. Furthermore, the impact of long-term vitamin K supplementation on vascular calcification has not been examined. In an ancillary study to a funded 3-year, double-blind, placebo controlled study on the effect of vitamin K supplementation on bone mineral density (BMD) and bone turnover, we propose to study the effect of vitamin K supplementation (500 g/d) on the progression of vascular calcification in 450 men and women, aged 60-80 years, who are already being monitored for bone loss. We will measure vascular calcification using electron beam computed tomography (EBCT) at the beginning and the end of 3 years of vitamin K supplementation. In addition, we will measure serum MGP and plasma lipids at 1, 6, 12, 24, and 36 months of vitamin K supplementation. Other covariates that will be collected through the course of the study as part of the funded study, include biochemical markers of vitamin K, vitamin D and calcium, markers of bone turnover, BMD of the hip, age, anthropometric data, physical activity, dietary intakes, medication use, and smoking. The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women.