ADAPTIVE IMMUNITY SUPPORTS SCHISTOSOME DEVELOPMENT

描述血吸虫属寄生吸虫感染影响全世界2亿人，主要在发展中国家。研究涉及S. Mansoni等人提出，寄生虫在哺乳动物宿主内发育和迁移的成功完成取决于寄生虫接收适当的宿主来源的信号以及雄性和雌性寄生虫之间的信号传递。对这些相互作用中所涉及的信号和受体的分子理解可能会揭示新的机会，以破坏寄生虫的生命周期，用于治疗或预防目的。我们发现，S.鼠宿主中的曼氏曼氏菌依赖于宿主在免疫应答期间产生的适应性免疫应答。该提案的目的是（i）确定负责促进寄生虫发育的精确免疫细胞和因子，以及（ii）确定参与介导宿主因子表型可塑性的寄生虫分子。这项工作的最终目标是确定新的机制，破坏寄生虫的生命周期的治疗和预防的目的

DESCRIPTION Infections with parasitic trematodes of the genus Schistosoma affect 200 million people worldwide, primarily in developing countries. Studies involving S. mansoni have suggested that successful completion of parasite development and migration within the mammalian host is dependent on the receipt of appropriate host-derived signals by the parasite and on transmission of signals between male and female parasites. A molecular understanding of the signals and receptors involved in these interactions may reveal new opportunities to disrupt the parasite life cycle for therapeutic or prophylactic purposes. We have now found that normal development of S. mansoni in the murine host is dependent on adaptive immune responses mounted by the host during prepatency. The aims of this proposal are to (i) identify the precise immune cells and factors responsible for promoting parasite development, and (ii) identify parasite molecules involved in mediating phenotypic plasticity to host factors. The ultimate goal of this work is to identify novel mechanisms for disrupting the parasite life cycle for therapeutic and prophylactic purposes