BRAIN ERPS AND COGNITIVE DEMAND IN SCHIZOPHRENIA

描述（改编自申请人摘要）：精神分裂症患者 已经显示出P3脑ERP对音调的振幅降低， 左颞叶最大。 在项目初期， 研究者在双耳分听复合音任务中重复了这一发现， 发现精神分裂症患者的N2振幅和不对称性降低， 二分音节任务 这表明，左半球功能障碍， 精神分裂症的言语处理发生早在200毫秒后刺激 发病 精神分裂症患者的N2异常存在于两个 听觉和视觉任务，而P3异常似乎是模态 特定. 研究人员建议进行四项研究，以确定 产生这些ERP所需的任务和患者特征 并进一步解决其神经生理机制。 研究1将记录大样本精神分裂症患者的ERP（n=120） 和正常对照组（n=40）的语言和非语言双耳oddball任务， 并且将评估响应模式（无声计数，右手）的影响 或左手）。 这些大样本将使研究人员能够检查 精神分裂症ERP异常与症状特征、 抗精神病药治疗的结果，精神分裂症家族史， 和神经影像学检查 研究2将开发和应用新的口头和 非语言任务，结合了双耳分听的优势 程序，但使用一个简单的古怪的范例。 研究3比较了 精神分裂症患者和对照组听觉和视觉连续词 识别任务，这被认为反映了左内侧颞叶 功能 研究4继续研究者的视觉空间研究， 精神分裂症中的加工过程，使用旨在解开 选择性注意和后期认知加工的影响。 患者 将在停药期间和治疗六周后再次进行测试 与氟哌啶醇或非典型的精神安定药（氯氮平或利培酮）。 一 更长期的临床目标是促进 可以预测对常规或非典型治疗反应的测试 精神分裂症的抗精神病药物

DESCRIPTION (Adapted from applicant's abstract): Schizophrenic patients have shown a reduction in amplitude of the P3 brain ERP to tones, which was maximal over left temporal lobe sites. In the initial project period, the investigator replicated this finding in a dichotic complex tone task and found reduced N2 amplitude and asymmetry in schizophrenic patients in a dichotic syllable task. This suggests that left hemisphere dysfunction in schizophrenia for verbal processing occurs as early as 200 ms after stimulus onset. N2 abnormalities in schizophrenic patients were present in both auditory and visual tasks, whereas P3 abnormalities appear to be modality specific. The investigator proposes to conduct four studies to determine the task and patient characteristics necessary for producing these ERP abnormalities and to further resolve their neurophysiologic mechanisms. Study 1 will record ERPs in a large sample of schizophrenic patients (n=120) and normal controls (n=40) on verbal and nonverbal binaural oddball tasks, and will assess the influence of response mode (silent counting, right hand or left hand). These large samples will enable the investigator to examine the relation of ERP abnormalities in schizophrenia to symptom features, outcome of treatment with neuroleptics, familial history of schizophrenia, and neuroimaging measures. Study 2 will develop and apply new verbal and nonverbal tasks that incorporate advantages of dichotic listening procedures, but utilize a simple oddball paradigm. Study 3 compares ERPs of schizophrenic patients and controls in auditory and visual continuous word recognition tasks, which are thought to reflect left medial temporal lobe function. Study 4 continues the investigator's study of visuospatial processing in schizophrenia using a revised paradigm designed to disentangle effects of selective attention and later cognitive processing. Patients will be tested while off medication and again after six weeks of treatment with haloperidol or an atypical neuroleptic (clozapine or risperidone). A more long range clinical goal is to contribute toward the development of tests that could predict response to treatment with conventional or atypical neuroleptic medications for schizophrenia.