SODIUM EFFECTS ON BONE METABOLISM

候选人劳拉·卡伯恩医学博士是该领域的一名新研究员。 代谢性骨病。近期目标包括获得以下方面的专业知识 研究设计。这将由共同导师持续提供 Genaro Palmieri博士，代谢性骨骼疾病方面的知名专家，以及 威廉·B·阿普盖特博士，大型多中心临床试验专家。 长期目标包括获得临床所需的技能 代谢性骨病试验。这将由该中心提供 每周一次的统计和流行病学课程，营养学和 骨质疏松症和一个导致科学硕士学位的项目 流行病学。具体研究计划详述如下： 骨代谢、骨密度和骨折的种族差异 据报道，高加索人和非裔美国人之间的比率 高加索人通常有更多的骨生化标志 新陈代谢，骨密度降低，骨折发生率高于 非裔美国人。然而，最近的数据表明，这种发病率 在非洲，骨质疏松性和骨质疏松性骨折的发病率可能正在增加 美国人。 环境因素，特别是盐的摄入量，已经被证明是 对高加索人骨代谢的影响，但尚未在 非洲裔美国人，尽管非洲裔美国人的饮食可能是 钠含量很高。 这项研究建议检查钠负荷的影响，然后 促钙激素和生化标志物的限钠饮食 非裔美国人和高加索女性的骨代谢。

The candidate, Laura Carbone M.D., is a new investigator in the field of metabolic bone diseases. Immediate goals include acquiring expertise in study design. This will be provided on a ongoing basis by the co-mentors Dr. Genaro Palmieri, a well known expert in metabolic bone disease, and Dr. William B. Applegate, an expert in large multi-center clinical trials. Long term goals include obtaining the skills necessary to do clinical trials in metabolic bone diseases. This will be provided at this center by weekly classes in statistics and epidemiology, seminars in nutrition and osteoporosis and a program leading to a master of science degree in epidemiology. The specific research plan is detailed below: Racial differences in bone metabolism, bone mineral density and fracture rates have been reported between Caucasians and African Americans with Caucasians generally having increased biochemical markers of bone metabolism, decreased bone mineral density and higher fracture rats than African Americans. More recent data, however, suggests that the incidence of osteoporosis and osteoporotic fractures may be increasing in African Americans. Environmental factors, specifically salt intake, have been shown to influence bone metabolism in Caucasians, but have not been studied in African Americans, despite the fact that the African American diet may be high in sodium. This study proposes to examine the effects of sodium load and then a sodium restriction diet of calciotropic hormones and biochemical markers of bone metabolism in African American and Caucasian women.