Gordon Research Conference on Basement Membranes

描述（由申请人提供）：本申请要求部分资金 感谢2002年戈登地下室会议特邀发言人的支持 膜。这是一系列会议中的第十一次， 一个国际论坛，传播关于非洲的新思想和新信息， 基底膜（BM）的结构和功能。这些都是复杂的，三个 在上皮间充质细胞形成三维细胞外结构 界面和周围的间充质细胞，具有重要的作用， 大多数组织和器官的组织和功能，例如，血管， 肺、肾、皮肤、周围神经和肌肉。例如，地下室 膜调节细胞的迁移和组织， 肌肉骨骼系统，以及神经系统中的轴突和突触。 编码基底膜成分的基因突变导致严重的 人类的遗传性疾病（例如，先天性皮肤大疱性表皮 肌营养不良和相关的神经缺陷，Alport综合征的肾）。 基底膜的获得性缺陷也有助于 糖尿病微血管疾病并作为感染因子的进入部位， 例如麻风病和转移性癌细胞。传统上，会议 吸引了来自基础研究各个领域的科学家， 包括蛋白质和碳水化合物结构、基因表达、细胞和 发育生物学和神经生物学。此外，出席会议的还有 临床医生和科学家参与研究和/或治疗人类 涉及肺、血管、皮肤、肾、骨的BM组分的病症， 肌肉和免疫系统。BM降解和周转的基础研究是 科学家们也对研究动态过程感兴趣， 血管生成、癌症转移、胚胎植入和 乳腺和子宫。临床医生对这一研究 以及制药和生物技术行业的科学家， BM在伤口愈合、血管生成、神经再生、炎症 和组织修复。会议将举行各种会议， 基底膜和细胞外基质（ECM）的基础科学 结构、生物合成、组装、周转和功能。比较研究 BM在脊椎动物和无脊椎动物中的功能以及BM和ECM在 胚胎发育也将纳入计划。此外，本发明还提供了一种方法， 重点是BM和ECM的遗传分析研究 功能，以及人BM疾病的动物模型的产生。

DESCRIPTION (provided by applicant): This application requests partial funding for the support of invited speakers for the 2002 Gordon Conference on Basement Membranes. This is the eleventh in a series of conferences, which have become an international forum for dissemination of new ideas and information about the structure and functions of basement membranes (BMs). These are complex, three dimensional, extracellular structures formed at epithelial mesenchymal interfaces and around mesenchymal cells, with important roles in the organization and function of most tissues and organs, e.g., blood vessels, lung, kidney, skin, peripheral nerves, and muscle. For example, basement membranes regulate the migration and organization of cells in the musculoskeletal system, as well as axons and synapses in the nervous system. Mutations in genes encoding basement membrane components result in severe inherited disorders in humans (e.g., epidermolysis bullosa of skin, congenital muscular dystrophy and associated nerve defects, Alport syndrome of kidney). Acquired defects in basement membranes also contribute to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells. Traditionally, the conference has attracted scientists from a wide range of fields in basic research, including protein and carbohydrate structure, gene expression, cell and developmental biology, and neurobiology. In addition, it has been attended by clinicians and scientists involved in research and/or treatment of human disorders involving BM components of lung, blood vessels, skin, kidney, bone, muscle and immune systems. Basic studies of BM degradation and turnover are also of interest to scientists investigating dynamic processes such as angiogenesis, cancer metastasis, embryo implantation, and involution of the mammary gland and uterus. There has been substantial interest from clinicians and scientists in the pharmaceutical and biotechnology industries studying the roles of BMs in wound healing, angiogenesis, nerve regeneration, inflammation, and tissue repair. The Conference will present a diverse mixture of sessions on the basic science of basement membrane and extracellular matrix (ECM) structure, biosynthesis, assembly, turnover, and functions. Comparative studies of BM function in vertebrates and invertebrates and the roles of BM and ECM in embryonic development will also be incorporated into the program. In addition, emphasis will be given to studies on the genetic analyses of BM and ECM functions, and the generation of animal models of human BM disorders.