Gordon Conference: Second Messengers and Phosphorylation

描述（由申请人提供）：我请求部分支持戈登研究会议（GRC）第二信使和蛋白质磷酸化会议的运作。这个GRC通常在新罕布什尔州Meridin的Kimball Union Academy举行，它提供了一个熟悉的场所来促进参与者之间的开放互动。本次GRC于2002年6月9日星期日晚上开始，由一位全体发言人主持，并于6月13日星期四晚上结束。会议重点关注调节细胞生长、生存和代谢的蛋白激酶信号转导机制。充分了解这些信号机制在科学和临床上都具有重要意义，因为它们的失效在影响全世界数百万人的当代健康问题中起着直接作用。我们鼓励演讲者将生化、结构、细胞生物学和基因组学方法结合起来，提供对信号机制分子方面的全面理解。会议将选出全体会议发言人，为会议搭建舞台，并挑战与会者从一个新的角度思考信号转导。会议将由8个会议组成，每个会议由一位讨论主持人和至少四名演讲者组成，演讲者从最近做出重要贡献的研究人员中选出；至少20%的发言者是女性或少数民族成员。每个会议的演讲者将发展信号转导中重要范例的结构和功能，并将这些系统与疾病机制和潜在的治疗策略联系起来。我将从申请者中选出135名参与者，包括产学研代表、资深科学家、博士后和研究生。鼓励参加者在每天下午张贴有关最新有趣成果的海报。重要的是，会议为年轻研究者提供了一个论坛，让他们看到基础科学探究与科学方法应用于设计有效干预人类疾病（包括癌症、糖尿病、肥胖、衰老和神经变性）之间的联系。为了强调这一目标，将在主要会议期间选出四份与会议主题相辅相成的海报报告作简短的口头报告。

DESCRIPTION (provided by applicant): I am requesting partial support for the operation of the Gordon Research Conference (GRC) Conference on Second Messengers and Protein Phosphorylation. This GRC is usually held at Kimball Union Academy in Meridin, New Hampshire, which provides a familiar venue to promote open interaction among participants. This GRC begins on Sunday night June 9, 2002 with a plenary speaker and concludes on Thursday evening June 13. The Conference focuses on protein kinase signal transduction mechanisms that regulate cellular growth, survival and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide. The speakers are encouraged to integrate biochemical, structural, cell biological and genomic approaches into providing a comprehensive understanding of the molecular aspects of signaling mechanisms. The plenary speaker will be selected to set the stage for the conference and challenge the participants to think about signal transduction from a novel perspective. The conference will consist of 8 sessions, each with a discussion leader and at least four speakers, selected from investigators who have made important recent contributions; at least 20% of the speakers are women or members or minorities groups. Speakers in each session will develop the structure and function of important paradigms in signal transduction and relate these systems to disease mechanisms and potential treatment strategies. I will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. Participants are encouraged to present poster on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human diseases, including cancer, diabetes, obesity, aging and neurodegeneration. To emphasize this goal, four poster presentations that complement the theme of the meeting will be selected for brief oral presentations during the major sessions.