FASEB Summer Conference--Advance in Tetraspanin Research

本申请为FASEB将于2002年6月15日至6月20日在亚利桑那州图森举行的四跨蛋白2002夏季研究会议寻求部分资金。这将是第二次专门讨论这个广泛表达的多功能蛋白质超家族的会议。随着在包括哺乳动物、线虫、果蝇和血吸虫在内的广泛物种中发现新成员，对该家族的兴趣迅速增长。最近取得进展的几个领域包括解决CD81的大细胞外环的结构，鉴定与四蛋白蛋白紧密或松散相关的其他蛋白质宿主，以及几种基因敲除小鼠的产生。比以往任何时候都更重要的是，该领域的研究人员现在准备揭示四跨蛋白对细胞运动、融合、信号传导和其他功能的贡献背后的基本机制。会议将涵盖以下相关领域的最新进展：传染病（丙型肝炎病毒结合、白炽毒素、病毒诱导合胞体形成）、脑功能（神经突生长、星形胶质细胞、雪旺细胞、少突胶质细胞功能）、生育（精子-卵子融合）、发育/分化（肌肉形成、成骨和造血、膀胱发育）、免疫功能（T和B细胞信号传导、共刺激、TH1/TH2比率、IgM产生）、肿瘤生长和转移（肿瘤抑制，促进转移），以及其他人类疾病，视网膜疾病，x连锁智力低下)。在此之前，只有一次四氰胺会议（2000年7月），而且取得了压倒性的成功。未安排其他相关会议。会议将遵循FASEB的标准会议形式，共9次会议，超过4.5天，每次会议有3-4个主要演讲。受邀的与会者将包括广泛的临床医生、肿瘤学家、细胞和发育生物学家、免疫学家、基础生物化学家和分子生物学家。我们将尽一切努力平衡演讲者和与会者的分布（新的，老牌的；学术的，工业的；男性的，女性的；美国的，其他国家的等等）。随着来自如此多不同领域的研究人员聚集在一起，与人类病理生理过程相关的共同主题应该出现。随着基因组学、蛋白质组学和遗传技术的应用，大量的新信息将会出现。

This application seeks partial funding for the FASEB 2002 Summer Research Conference on Tetraspanins to be held June 15- June 20, 2002 in Tucson, Arizona. This will be the second conference ever to be dedicated to this superfamily of widely expressed, multifunctional proteins. The interest in the family has been growing rapidly with new members being identified in a wide range of species including mammals, nematodes, drosophila, and Schistosomes. A few areas of recent progress include the solving of the structure for the large extracellular loop of CD81, the identification of a host of other proteins that are either tightly or loosely associated with tetraspanins, and the production of several knockout mice. More so than ever before, researchers in the field are now poised to uncover fundamental mechanisms behind the contributions of tetraspanins towards cell motility, fusion, signaling, and other function. The conference will cover recent progress in areas of relevance to infectious disease (binding of hepatitis C virus, diphtheria toxin, virus induced syncytia formation), brain function (neurite outgrowth, astrocyte, schwann cell, oligodendrocyte functions), fertility (sperm-egg fusion), development/differentiation (myogenesis, osteogenesis and hematopoiesis, bladder development), immune function (T and B cell signaling, co-stimulation, TH1/TH2 ratios, IgM production), tumor growth and metastasis (tumor suppression, metastasis promotion), and other human diseases, retinal disease, X-linked mental retardation). There has been only one previous tetraspanin conference (in July, 2000), and that was overwhelmingly successful. No other related conferences are scheduled. The meeting will follow the standard FASEB meeting format, with 9 sessions, over 4.5 days, with 3-4 major presentations in each session. Invited attendees will include a broad spectrum of clinicians, oncologists, cell and developmental biologists, immunologists, and basic biochemists and molecular biologists. Every attempt will be made to have a balanced distribution of presenters and attendees (new, established; academic, industrial; male, female; USA, other countries; etc.). With researchers from so many diverse area being brought together, common themes relevant to human pathophysiological processes should emerge. With the recent application of newly available genomic, proteomic, and genetic technologies, an abundance of new information should be forthcoming.