Transplantation Immunology Conference

描述（由申请人提供）：这是一个申请部分 资助即将举行的“移植免疫学”会议 在佛蒙特州萨克斯顿河佛蒙特学院FASEB的赞助下， 2002年15-20日。这个新的FASEB会议主题将反映最近，重要的 分子和细胞免疫学的发展， 提高对移植排斥机制基础的理解， 宽容同样重要的是，这些发现对 开发细胞和器官移植排斥的改进疗法， 最终导致临床移植的持续实现 宽容重点将放在会议的最新见解 将致力于1）同种异体识别和淋巴细胞活化; 2） 内皮细胞-白细胞相互作用和趋化因子的作用; 3） 内皮细胞在慢性排斥反应中的作用及其预防; 4）新的 共刺激通路、细胞因子和凋亡; 5）免疫中的树突状细胞 反应性和耐受性; 6）调节细胞; 7）临床方法 移植耐受和8）异种移植，干细胞生物学和 克隆。这次会议的一个重要方面将是互动 在基础免疫学和分子生物学领域 遗传学/生物学和移植科学家和临床医生。约 180名参与者将从最有可能的研究者中选出 分享最新的知识，并促进激励 交流思想/观念。演讲者和海报展示者将是那些 最近做出了最大的贡献。也会有两个 海报展示会。会议将提供一个重要论坛 为来自广泛的子专业的贡献者之间的对话。的 总体结果应是对以下方面的概述和综合观点/共识： 这个快速发展的应用生物医学领域。一个重要目标 将是未来研究方向的评价，以及关键 当代“前沿”研究的评价。

DESCRIPTION (provided by applicant): This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB at Vermont Academy, Saxton's River, Vermont, June 15-20, 2002. This new FASEB conference topic will reflect recent, important developments in molecular and cellular immunology that have direct relevance to improved understanding of the mechanistic basis of transplant rejection and tolerance. Equally significant, are the implications of these findings for the development of improved therapies of cell and organ graft rejection, that may lead ultimately, to the consistent achievement of clinical transplantation tolerance. Emphasis will be placed on the most recent insights in sessions that will be devoted to 1) allorecognition and lymphocyte activation; 2) endothelial cell-leukocyte interaction and the role of chemokines; 3) endothelial cells in chronic rejection and its prevention; 4) novel costimulatory pathways, cytokines, and apoptosis; 5) dendritic cells in immune reactivity and tolerance; 6) regulatory cells; 7) approaches to clinical transplantation tolerance and 8) xenotransplantation, stem cell biology and cloning. An important aspect of this conference will be the interaction between scientists with expertise in basic immunology and molecular genetics/biology and transplantation scientists and clinicians. Approximately 180 participants will be selected from amongst those investigators most likely to share the most recent new knowledge, and to contribute to stimulating exchange of ideas/concepts. Speakers and poster presenters will be those who have made the most significant recent contributions. There will also be two poster presentation sessions. The conference will provide an important forum for dialogue between contributors from a broad range of subspecialties. The aggregate result should be an overview and integrated perspective/consensus of this rapidly moving field of applied biomedical science. An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research.