NUCLEAR TRANSCRIPTION FACTOR ROLE IN T CELL ACTIVATION A

核转录因子、核因子B(如P52)家族和I B(如P52)家族。 Bcl-3)家族，在肿瘤细胞的反应中起关键作用。 免疫系统。对这些蛋白质的体外活性进行了检测。 但它们在体内的作用尚未被记录在案。Bcl-3基因缺陷小鼠 和p52的产生是为了解决这些基因的体内功能 蛋白质。Bcl3基因缺陷小鼠和P52基因缺陷小鼠均表现出 重叠的表型，因为他们在脾中有缺陷 微结构、生发中心反应和体液反应。在… 同时，它们各自表现出一些独特的特点。这些 这一发现证明了这些蛋白质的体内功能，特别是 关于B细胞的功能。 该组织评估了重建造血细胞和 化疗后患者的淋巴系细胞。一个 重建的主要障碍来自移植物对宿主疾病，在 供者移植物中存在的哪些T细胞对受者产生反应。我们 也评估为治疗自身侵袭性免疫而设计的方案 多发性硬化症和关节炎等疾病。在这些疾病中， 病理由炎性免疫反应和电流介导 这些疾病的治疗策略旨在抑制 这些炎症反应。对细胞内的理解 这些反应的中介物和动物模型的创建 反映这些流程，例如本项目中使用的流程，是必不可少的 用于新疗法的开发和测试。此外，这项研究还 需要深入了解免疫荧光、流式细胞术和 细胞因子分析，赞助商用来评估他们的 产品和临床前/临床结果。

Nuclear transcription factors, NF- B (e.g. p52) family and I B (e.g. Bcl-3) family, play a critical role in the response of cells of the immune system. The in vitro activity of these proteins has been examined but their in vivo role had not been documented. Mice deficient in Bcl-3 and p52 were generated in order to address the vivo function of these proteins. Both Bcl-3-deficient and p52-deficient mice exhibited overlapping phenotypes in that they had defects in splenic microarchitecture, germinal center reactions, and humoral responses. At the same time, they each exhibited some unique characteristics. These finding demonstrate an in vivo function for these proteins, particularly in regard to B cell function. This group evaluates protocols for the reconstitution of hematopoietic and lymphoid lineage cells in patients who have received chemotherapy. A major impediment to reconstitution comes from graft vs host disease, in which T cells present in the donor graft react against the recipient. We also assess protocols designed for the treatment of autoaggressive immune diseases such as multiple sclerosis and arthritis. In these diseases, pathology is mediated by inflammatory immune responses and current strategies for the treatment of these diseases is directed at suppressing these inflammatory responses. An understanding of the intracellular mediators of these responses and the creation of animal models that reflect these processes, such as those used in this project, are essential for the development and testing of new therapies. Moreover, this research require an in depth knowledge of immunfluorescence, flow cytometry, and cytokine assays, techniques which are used by sponsors to assess their products and preclinical/clinical results.